个人简介

2012年博士毕业于武汉大学口腔医学院，并留校工作。2013-2014年于武汉大学化学与分子科学学院从事博士后研究；2015-2017年于美国宾夕法尼亚大学生物学系从事博士后研究。2019年度获批国家优秀青年科学基金，2020年度获批湖北省杰出青年基金，2015年入选“武汉市中青年医学骨干人才培养工程”，2016年入选中国科协“青年人才托举工程”。以第一或通讯作者发表40篇，包括Nature,J Am Chem Soc,Angew Chem Int Ed,ACS Nano,Adv Funct Mater,J Extracell Vesicles,J Dent Res等国际权威期刊；申请国家发明专利15项（获授权8项）；主持国家自然科学基金4项，省部级基金5项。

教育经历

2012年博士毕业于武汉大学口腔医学院，并留校工作

工作经历

2019.11-至今 武汉大学口腔医院主任医师、教授

2015.12-2019.11 武汉大学口腔医院副主任医师、副教授

2014.12-2017.12 美国宾夕法尼亚大学生物学系博士后

2013.06-2014.12 武汉大学化学与分子科学学院博士后

2012.12-2015.11 武汉大学口腔医院主治医师

社会服务

1.中华口腔医学会口腔生物医学专业委员会常务委员

2.中华口腔医学会口腔医学教育专业委员会常务委员

3.中华口腔医学会口腔颌面-头颈肿瘤专业委员会 委员

4.中华口腔医学会口腔医学科研管理分会委员

5.《口腔生物医学》杂志编委

科研领域

本课题组主要研究方向为细胞外囊泡与肿瘤免疫。细胞外囊泡是细胞通过胞吐或膜出芽方式分泌到胞外的纳米级膜性小泡，广泛存在于血液、唾液、尿液等体液中，可携带丰富的生物活性分子，是机体内不可或缺的细胞间通讯载体。研究细胞外囊泡的生物学行为和功能及其与重大疾病的相关性不仅有助于揭示相关疾病的发病机制，还有望为疾病的早期诊断及预后评估提供新的液体活检标志物。

近年来，本课题组围绕细胞外囊泡与肿瘤免疫及治疗，开展完成以下3方面的研究工作：

（1）通过磁性/荧光纳米标记技术实现细胞外囊泡快速高质量分离及活体内实时动态示踪成像；

（2）通过纳米生物医学交叉研究揭示肿瘤细胞外囊泡的活体内代谢规律及特征性生物学行为；

（3）通过临床相关研究揭示细胞外囊泡调控肿瘤免疫逃逸的关键作用机制及其转化应用策略。

代表性论文

1. Xia HF^#, Lai WQ^#, Chen GH, Li Y, Xie QH, Jia YL,Chen G*, Zhao YF*.A histological study of vascular wall resident stem cells in venous malformations.Cell Tissue Res. 2022 Aug 2.

2. Chen GH^#, Yang JG^#, Xia HF, Zhang LZ, Chen YH, Wang KM, Duan X, Wu LZ, Zhao YF,Chen G*.Endothelial cells induce degradation of ECM through enhanced secretion of MMP14 carried on extracellular vesicles in venous malformation.Cell Tissue Res. 2022 Jul 4.

3. Yu ZL^#, Liu JY^#,Chen G*. Small extracellular vesicle PD-L1 in cancer: the knowns and unknowns.NPJ Precis Oncol. 2022 Jun 21;6(1):42.

4. Xie QH^#, Zheng JQ^#, Ding JY, Wu YF, Liu L, Yu ZL*,Chen G*. Exosome-Mediated Immunosuppression in Tumor Microenvironments.Cells. 2022 Jun 16;11(12):1946.

5. Yu ZL^#, Liu XC^#, Wu M, Shi S, Fu QY, Jia J*,Chen G*. Untouched isolation enables targeted functional analysis of tumour-cell-derived extracellular vesicles from tumour tissues.J Extracell Vesicles.2022 Apr;11(4):e12214.

6. Li Y^#, Duan X, Chen Y, Liu B,Chen G*.Dental stem cell-derived extracellular vesicles as promising therapeutic agents in the treatment of diseases.Int J Oral Sci.2022 Jan 4;14(1):2.

7. Li SR^#, Man QW^#, Gao X, Lin H, Wang J, Su FC, Wang HQ, Bu LL*, Liu B*,Chen G*. Tissue-derived extracellular vesicles in cancers and non-cancer diseases: Present and future.J Extracell Vesicles.2021 Dec;10(14):e12175.

8. Yu ZL^#, Zhao Y^#, Miao F, Wu M, Xia HF, Chen ZK, Liu HM, Zhao YF,Chen G*. In situ membrane biotinylation enables the direct labeling and accurate kinetic analysis of small extracellular vesicles in circulation.Anal Chem.2021 Aug 10;93(31):10862-10870.

9. Dong HY^#,Xie QH^#, Pang DW,Chen G*, Zhang ZL*. Precise selection of aptamers targeting PD-L1 positive small extracellular vesicles on magnetic chips.Chem Commun. 2021 Apr 14;57(29):3555-3558.

10. Xu CM^#, Tang M, Feng J, Xia HF, Wu LL, Pang DW,Chen G*, Zhang ZL*. A liquid biopsy-guided drug release system for cancer theranostics: integrating rapid circulating tumor cell detection and precision tumor therapy.Lab Chip.2020 Apr 21;20(8):1418-1425.

11. Tang M^#, Xia HF^#, Xu CM, Feng J, Ren JG, Miao F, Wu M, Wu LL, Pang DW,Chen G*, Zhang ZL*.Magnetic chip based extracorporeal circulation: a new tool for circulating tumor cell in vivo detection.Anal Chem.2019 Dec 3;91(23):15260-15266.

12. Zhong WQ^#, Ren JG^#, Xiong XP, Man QW, Zhang W, Gao L, Li C, Liu B, Sun ZJ, Jia J, Zhang WF, Zhao YF,Chen G*. Increased salivary microvesicles are associated with the prognosis of patients with oral squamous cell carcinoma.J Cell Mol Med.2019 Jun;23(6):4054-4062.

13. Chen G^#, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu ZL, Yang JG, Wang BK, Sun HH, Xia HF, Man QW, Zhong WQ, Antelo LF, Wu B, Xiong XP, Liu XM, Guan L, Li T, Liu SJ, Yang RF, Lu YT, Dong LY, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu YL, Kim JY, Chen YH, Dong HD, Zhao YF, Karakousis GC, Gangadhar TC, Schuchter LM, Herlyn M, Wherry EJ, Xu XW*, Guo W*.Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response.Nature.2018 Aug;560(7718):382-386.

14. Yu ZL^#, Zhang W, Zhao JY, Zhong WQ, Ren JG, Wu M, Zhang ZL, Pang DW, Zhao YF,Chen G*. Development of a dual-modally traceable nanoplatform for cancer theranostics using natural circulating cell-derived microparticles in oral cancer patients.Adv Funct Mater.2017; 27(40):1703482.

15. Xia HF^#, Ren JG^#, Zhu JY, Yu ZL, Zhang W, Sun YF, Zhao YF*,Chen G*. Downregulation of miR-145 in venous malformations: Its association with disorganized vessels and sclerotherapy.Eur J Pharm Sci.2017 Mar 30;100:126-131.

16. Zhang W^#, Yu ZL^#, Wu M, Ren JG, Xia HF, Sa GL, Zhu JY, Pang DW, Zhao YF*,Chen G*. Magnetic and folate functionalization enables rapid isolation and enhanced tumor-targeting of cell-derived microvesicles.ACS Nano. 2017 Jan 24;11(1):277-290.

17. Zhu JY^#, Ren JG^#, Zhang W, Wang FQ, Cai Y, Zhao JH,Chen G*, Zhao YF*. Characterization of microparticles in patients with venous malformations of the head and neck.Oral Dis. 2017 Jan;23(1):110-119.

18. Ren JG^#, Man QW^#, Zhang W, Li C, Xiong XP, Zhu JY, Wang WM, Sun ZJ, Jia J, Zhang WF, Zhao YF,Chen G*,Liu B*. Elevated level of circulating platelet-derived microparticles in oral cancer.J Dent Res.2016; 95(1):87-93.

19. Zhao JY^#,Chen G^#, Gu YP, Cui R, Zhang ZL, Yu ZL, Tang B, Zhao YF, Pang DW*. Ultrasmall magnetically engineered Ag₂Se quantum dots for instant efficient labeling and whole-body high-resolution multimodal real-time tracking of cell-derived microvesicles.J Am Chem Soc. 2016 Feb 17;138(6):1893-1903.

20. Ren JG^#, Zhang W^#, Liu B, Man QW, Xiong XP, Li C, Zhu JY, Wang WM, Jia J, Sun ZJ, Zhang WF,Chen G*, Zhao YF*. Clinical significance and roles in angiogenesis of circulating microparticles in oral cancer.J Dent Res. 2016; 95(8):860-867.

21. Zhu JY^#, Zhang W, Ren JG,Chen G*, Zhao YF. Characterization of endothelial microparticles induced by different therapeutic drugs for infantile hemangioma.J Cardiovasc Pharmacol. 2015; 66(3):261-269.

22. Zhang W,Chen G*, Wang FQ, Ren JG, Zhu JY, Cai Y, Zhao JH, Jia J, Zhao YF*. Macrophages contribute to the progression of infantile hemangioma by regulating the proliferation and differentiation of hemangioma stem cells.J Invest Dermatol.2015; 135(12):3163-3172.

23. Chen G^#, Zhu JY, Zhang ZL, Zhang W, Ren JG, Wu M, Hong ZY, Lv C, Pang DW*, Zhao YF*. Transformation of cell-derived microparticles into quantum-dot-labeled nanovectors for antitumor siRNA delivery.Angew Chem Int Ed.2015 Jan 12;54(3):1036-1040.

实验室简介

本课题组人员配备合理，专业结构多元化，是一支口腔医学、纳米分析化学、细胞和分子生物学及生物信息学等多学科交叉的研究团队。团队组成包括教授/主任医师1人，副教授/副主任医师3人，主治医师3人，博士后4人，研究助理3人，硕士研究生7人，博士研究生16人。团队成员中已有1人入选国家自然科学基金优秀青年科学基金、3人入选中国科协“青年人才托举工程”， 1人入选“中国博士后创新人才计划”、2人入选“武汉市中青年医学骨干人才培养工程”。本课题组能够紧密结合临床，从实际问题出发设计并解决临床问题，主要围绕细胞外囊泡与肿瘤免疫的基础和应用开展研究工作。