科研领域
病原生物通过分泌毒素、效应因子、或表面蛋白等直接或间接与宿主细胞相互作用，引起宿主细胞损伤、细胞信号通路激活或抑制，导致一系列疾病。课题组将围绕病原生物效应因子、宿主膜受体信号转导分子机制及靶向药物开发和疫苗设计方面开展工作。在前期工作中，在艰难梭菌感染领域，以第一作者(含共同)身份发表文章于Science，Nature Structural & Molecular Biology，Nature Communications等杂志。基于研究成果，获得多项具有应用前景的PCT专利。
研究兴趣：
1.病原效应因子与宿主之间相互作用分子机制研究
2.基于结构的靶向药物研发和疫苗设计
3.生物毒素的药用价值挖掘
代表性论文
1. Chen, P#., Tao, L#., Wang, T., Zhang, J., He, A., Lam, K. H., Liu, Z., He, X., Perry, K., Dong, M*. & Jin, R*. (2018) Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B, Science. 360, 664-669.
2. Chen, P#., Lam, K. H., Liu, Z., Mindlin, F. A., Chen, B., Gutierrez, C. B., Huang, L., Zhang, Y., Hamza, T., Feng, H., Matsui, T., Bowen, M. E., Perry, K. & Jin, R*. (2019) Structure of the full-length Clostridium difficile toxin B, Nature Structural & Molecular Biology. 26, 712-719.
3. Chen, P#., Zeng, J#., Liu, Z., Thaker, H., Wang, S., Tian, S., Zhang, J., Tao, L., Gutierrez, C. B., Xing, L., Gerhard, Ralf., Huang, L., Dong, M*. & Jin, R*. (2021) Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection, Nature Communications. 12, 3748.
4. Chen, P#., Tao, L., Liu, Z., Dong, M. & Jin, R. S*. (2019) Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B, The FEBS Journal. 286, 874-881.
5. Chen, P#., & Jin, R*. (2021). Receptor binding mechanisms of Clostridioides difficile toxin B and implications for therapeutics development. The FEBS Journal. doi:10.1111/febs.16310
6. Chen, P#., Liu, Z., Wang, X. J., Peng, J. H., Sun, Q. Q., Li, J. Z., Wang, M. X., Niu, L. W., Zhang, Z. Y., Cai, G*., Teng, M. K*. & Li, X*. (2015) Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations, PloS One. 10, e0120304.
7. Chen, P#., Li, J. Z., Ma, J., Teng, M. K*. & Li, X*. (2013) A Small Disturbance, But a Serious Disease: The Possible Mechanism of D52H-Mutant of Human PRS1 That Causes Gout, Iubmb Life. 65, 518-525.
8. Liu, Z#., Chen, P., Wang, X. J., Cai, G., Niu, L. W., Teng, M. K*. & Li, X*. (2014) Crystal structure of DnaT(84-153)-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode, Nucleic Acids Research. 42, 9470-9483.
9. Liu, Z#., Zhang, S., Chen, P., Tian, S., Zeng, J., Perry, K., Dong, M. & Jin, R*. (2021) Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B. Science Advances. 7, eabi4582.
10. He A#, Tian S#, Kopper O, Horan DJ, Chen P, Bronson RT, Sheng R, Wu H, Sui L, Zhou K, Tao L, Wu Q, Huang Y, Shen Z, Chen H, He X, Robling AG, Jin R, Clevers H, Xiang D*, Li Z*, Dong M*. (2023). Targeted inhibition of Wnt signaling with a Clostridioides difficile toxin B fragment suppresses breast cancer tumor growth. PLoS Biol, 21(11), e3002353. doi:10.1371/journal.pbio.3002353.
实验室简介
欢迎具有博士学位或即将获得博士学位，具有生化与分子生物学、细胞生物学、结构生物学或微生物学等相关专业背景的青年学者加入团队。
