个人简介

实验室研究方向是真菌的致病机理，致力于探索人类病原真菌形态转换的调控机制、对宿主微环境信号的感受方式和营养代谢途径和病原真菌和宿主免疫系统互作机制。取得的研究成果以通讯或第一作者发表在Nature Cell Biology、Cell Host & Microbe、Nature Communications、PNAS、PLoS Biology、mBio、和PLoS Pathogens等杂志上。曾受邀为Trends in Microbiology撰写关于白念珠菌研究进展的综述。

教育经历

1998-2002，吉林大学，学士

2002-2008，中科院生化细胞所，博士

工作经历

2008-2015，加州大学欧文分校，博士后，助理研究员

2016-现在，武汉大学生命科学学院，教授

荣誉奖励

国家高层次人才青年项目2016

科研领域

目前，真菌感染随着广谱抗生素的滥用和介入性治疗的广泛应用呈现逐年上升的趋势。其中，白念珠菌是人体内一种最常见的机会型致病真菌，60-70%侵入性真菌感染是由白念珠菌引起的。本实验室将以探究白念珠菌致病机制为基础来建立致病真菌与宿主互作关系的实验平台（整合遗传学、生物化学、系统生物学和实验动物感染模型），以期找到新的药物靶点来有效对抗真菌的系统性感染。 主要研究工作包括：1）真菌对宿主体内环境因子的感受器的鉴定和分子机制研究；2）病原真菌从共生菌到致病菌的转换机理；3)真菌的效应因子调控宿主免疫系统的机制；4）真菌耐药机制的研究以及抗真菌药物的筛选。

代表性论文

1. Mao Zhang, Cheng Zhu, Yuanyuan Duan, Tongbao Liu, Haoping Liu, Chang Su* andYang Lu*. (2022)The intrinsicallydisordered regionfromPP2C phosphatasesfunctions as a conserved CO₂sensor.Nature Cell Biology24 (7) 1029-1037

   Highlighted atNature Reviews Molecular Cell Biology,CO₂sensing through PP2C condensates.23 (4) 519Highlighted atNature Cell Biology,Intrinsically disordered CO₂sensors.24 (7) 1013-1014Highlighted atNature Chemical Biology, Sensing the air.18 (8) 793Recommended byFaculty Option.

2. Kang Xiong^#, Chang Su^#, Qiangqiang Sun andYang Lu*.Efg1 and Cas5 Orchestrate Cell Wall Damage Response to Caspofungin in Candida albicans.Antimicrobial Agents and Chemotherapy65 (2) e01584-20

3. Qiangqiang Sun, Kang Xiong, Yuncong Yuan, Jing Yu, Lianjuan Yang, Chao Shen, Chang Su*, andYang Lu*. (2019) Inhibiting fungal echinocandin resistance by small-molecular disruption of geranylgeranyltransferase type I activity.Antimicrobial Agents and Chemotherapy64 (2)02406-19

4. Yang Lu*^#; Chang Su^#; Shatarupa Ray; Yuncong Yuan; Haoping Liu*. (2019) CO2 signaling through the Ptc2-Ssn3 axis governs sustained hyphal development of Candida albicans by reducing Ume6 phosphorylation and degradation.mBio10 (1) 02320-18

5. Chang Su#; Jing Yu#; Qiangqiang Sun; Qian Liu;Yang Lu*. (2018) Hyphal induction under the condition without inoculation in Candida albicans is triggered by Brg1-mediated removal of NRG1 inhibition.Molecular Microbiology108(4): 410-423

6. Chang Su#;Yang Lu#; Haoping Liu. (2016) N-acetylglucosamine sensing by a GCN5-related N-acetyltransferase induces transcription via chromatin histone acetylation in fungi.Nature Communications7:12916

7. Yang Lu, Chang Su, and Haoping Liu. (2014) Candida albicans hyphal initiation and elongation.Trends in Microbiology22(12): 707-14.

8. Yang Lu^#, Chang Su^#, Ohimai Unoje, and Haoping Liu*. (2014) Quorum sensing controls hyphal initiation in Candida albicans through Ubr1-mediated protein degradation.Proc Natl Acad Sci111(5): 1975-80.Recommended byFaculty 1000.

9. Yang Lu, Chang Su, Norma V. Solis, Scott G. Filler, and Haoping Liu*. (2013) Synergistic regulation of hyphal elongation by hypoxia, CO2, and nutrient conditions controls the virulence of Candida albicans.Cell Host & Microbe14(5): 499-509.

   Recommended byFaculty 1000.

10. Yang Lu, Chang Su, and Haoping Liu*. (2012) A GATA transcription factor recruits Hda1 in response to reduced Tor1 signaling to establish a hyphal chromatin state in Candida albicans.PLoS Pathogens8(4): e1002663.

11. Yang Lu, Chang Su, Allen Wang, and Haoping Liu*. (2011) Hyphal development in Candida albicans requires two temporally linked changes in promoter chromatin for initiation and maintenance.PLoS Biology9(7): e1001105.Recommended byFaculty 1000.

12. Yang Lu, Chang Su, Xuming Mao, Prashna Pala Raniga, Haoping Liu*, and Jiangye Chen*. (2008) Efg1-mediated recruitment of NuA4 to promoters is required for hypha-specific Swi/Snf binding and activation in Candida albicans.Molecular Biology of the Cell19(10): 4260-72.

实验室简介