个人简介

教育经历

2008 - 2012 中山大学，生命科学学院，生物科学，学士

2012 - 2017 中科院生化细胞所，生物化学与分子生物学，博士工作经历

工作经历

2017 - 2022 美国德克萨斯大学西南医学中心，分子遗传系，博士后

2022 - 2024 美国德克萨斯大学西南医学中心，分子遗传系，资深研究专家

2024 - 至今 武汉大学泰康医学院（基础医学院），教授，泰康生命医学中心，PI

荣誉奖励

国家级人才计划入选者

科研领域

胆固醇约占细胞膜脂质的20％，在维持细胞膜的完整性、流动性和功能性方面发挥着关键作用。胆固醇还是类固醇激素、胆汁酸和维生素D的合成前体，它的代谢平衡影响了细胞内众多生理和生化过程。本课题组长期从事胆固醇代谢的功能机制研究，利用结构生物学、生物化学和分子生物学等手段，深入探寻胆固醇稳态调控的分子机制和参与调控的新成员，为治疗相关疾病提供新思路和新方法。

代表性论文

1. Long, T. #, Li, D. #, Vale, G., Jiang, Y., Schmiege, P., Yang, Z., McDonald, J., Li, X. (2024) Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake. Cell, in press. (#co-first author)

2. Long, T. #, Zhang, Y. #, Donnelly, L., Li, H., Pien, Y.C., Liu, N., Olson, E.N. and Li, X. (2023) Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion. Nat Struct Mol Biol, 30, 1746-1754. (#co-first author)

3. Long, T.*, Debler, E.W. and Li, X. * (2022) Structural enzymology of cholesterol biosynthesis and storage. Curr Opin Struct Biol, 74, 102369. (*corresponding author)

4. Long, T., Liu, Y., Li, X. (2021) Molecular structures of human ACAT2 disclose mechanism for selective inhibition. Structure, 29, 1410-1418.e1414.

5. Long, T. #, Liu, Y. #, Qin, Y., DeBose-Boyd, R.A. and Li, X. (2021) Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption. Sci Adv, 7. (#co-first author)

6. Sun, Y. #, Wang, J.#*, Long, T. #, Qi, X. #, Donnelly, L., Elghobashi-Meinhardt, N., Esparza, L., Cohen, J.C., Xie, X.S., Hobbs, H.H. et al. (2021) Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc. Natl. Acad. Sci. U. S. A., 118. (#co-first author)

7. Long, T. #, Sun, Y.#, Hassan, A., Qi, X. and Li, X. (2020) Structure of nevanimibe-bound tetrameric human ACAT1. Nature, 581, 339-343. (#co-first author)

8. Liu, R.J. #, Long, T. #, Li, H., Zhao, J., Li, J., Wang, M., Palencia, A., Lin, J., Cusack, S. and Wang, E.D. (2020) Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond. Nucleic Acids Res, 48, 4946-4959. (#co-first author)

9. Long, T., Qi, X., Hassan, A., Liang, Q., De Brabander, J.K. and Li, X. (2020) Structural basis for itraconazole-mediated NPC1 inhibition. Nat Commun, 11, 152.

10. Long, T., Hassan, A., Thompson, B.M., McDonald, J.G., Wang, J. and Li, X. (2019) Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition. Nat Commun, 10, 2452.

实验室简介