个人介绍

田剑波，博士生导师，公共卫生学院流行病与卫生统计学系副主任、国家优青和湖北省杰青获得者，并入选中国科协“青年人才托举”工程项目，主要从事于肿瘤分子流行病学研究。

教育经历

2010-2015 华中科技大学 预防医学 学士

2015-2020 华中科技大学 流行病与卫生统计学 博士

工作经历

2020.11-2021.08 华中科技大学 讲师

2021.09-2023.12 武汉大学 副教授

2024 -至今 武汉大学 教授

社会服务

中国抗癌协会肿瘤流行病专委会 委员

中国抗癌协会肿瘤病因专委会 委员

精准预防专业委员会 委员

中国抗癌协会腹膜肿瘤整合康复专委会 常委

中华肿瘤杂志 青年编委

执教课程

本科生课程：流行病学、预防医学、临床流行病学、卫生统计学

研究生课程：公共卫生前沿概论、分子流行病学、卫生统计学

科研领域

主要从事结直肠癌为主的肿瘤分子流行病学研究，聚焦肿瘤遗传易感新机制的解读和肿瘤高风险人群的精准识别开展一些原创性工作：①发现高效应易感位点并解析其易感新机制，拓展肿瘤易感基因谱；②识别非编码区功能性调控位点并揭示其调控机制，破译基因“荒漠区”奥秘；③鉴定关键癌变通路中的基因-环境和基因-基因交互作用模式，为构建肿瘤风险预测模型提供有效工具，进一步深化对肿瘤复杂病因的认识，为肿瘤个体化精准筛查提供理论依据。近5年以第一或通讯作者在Lancet Oncol、Nat Genet、Gastroenterology、Gut、Ann Oncol、Nat Commun、Am J Hum Genet和Cancer Res等杂志发表论文30余篇，国家发明专利6项，并受到较多的正面引用和转化应用。

研究方向：

1、肿瘤多组学、跨维度数据整合分析

2、肿瘤动态演变图谱描述和遗传易感新机制解读

3、肿瘤早期筛查和疾病风险预测模型构建

代表性论文

1．Zhang Ming^#, Chen Can^#, Lu Zequn^#, …, Zhu Ying, Tian Jianbo*, Miao Xiaoping*. Genetic Control of Alternative Splicing and its Distinct Role in Colorectal Cancer Mechanisms. Gastroenterology 2023, 0016-5085(23)04839-4;

2．Ying Pingting^#, Chen Can^#, Lu Zequn ^#, …, Zhu Ying, Tian Jianbo*, Miao Xiaoping*. Genome-wide enhancer-gene regulatory maps link causal variants to target genes underlying human cancer risk. Nature Communications 2023,14(1):5958;

3．Wang Haoxue^#, Cai Yimin^#, Jin Meng^#, …, Li Ni*, Tian Jianbo*. Identification of specific susceptibility loci for the early-onset colorectal cancer. Genome Medicine 2023,15(1):13;

4．Chen Can^#, Cai Yimin^#, …, Yang Xiaojun*, Zhu Ying*, Tian Jianbo*. Pan-Cancer Analysis of Microbiome Quantitative Trait Loci. Cancer Research 2022, 82(19):3449-3456;

5．Tian Jianbo^#, Zhu Ying#, Rao Meilin, …, Zhong Rong, Chang Jiang*, Miao Xiaoping*. N6-methyladenosine mRNA methylation of PIK3CB regulates AKT signalling to promote PTEN-deficient pancreatic cancer progression. Gut, 2020, 69(12): 2180-2192;

6．Tian Jianbo^#, Yuan Xianglin#, Xiao Jun#, …, Miao Xiaoping, Wang Zhihua. Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study. Lancet Oncology, 2020, 21(7): 893-903;

7．Tian Jianbo^#*, Chen Can^#, Rao Meilin^#, …, Zhu Ying, Yang Xiaojun*, Miao Xiaoping*. Aberrant RNA splicing is a primary link between genetic variation and pancreatic cancer risk. Cancer Research 2022, 82(11):2084-2096;

8．Tian Jianbo^#, Cai Yimin^#, Li Yue, …, Zhong Rong, Chang Jiang, Miao Xiaoping. CancerImmunityQTL: a database to systematically evaluate the impact of genetic variants on immune infiltration in human cancer. Nucleic Acids Research, 2021, 49(D1): D1065-D1073;

9．Tian Jianbo^#, Lou Jiao^#, Cai Yimin, …, Zhong Rong, Chang Jiang, Miao Xiaoping. Risk SNP-Mediated Enhancer-Promoter Interaction Drives Colorectal Cancer through Both FADS2 and AP002754.2. Cancer Research, 2020, 80(9): 1804-1818. (IF: 12.701);

10．Tian Jianbo^#, Chang Jiang^#, Gong Jing, …, Zhong Rong, Cai Kailin, Miao Xiaoping. Systematic Functional Interrogation of Genes in GWAS Loci Identified ATF1 as a Key Driver in Colorectal Cancer Modulated by a Promoter-Enhancer Interaction. American Journal of Human Genetics, 2019, 105(1): 29-47；

11．Tian Jianbo^#, Wang Zhihua^#, Mei Shufang, …, Gong Jing^*, Han Leng^*, Miao Xiaoping^*. CancerSplicingQTL: a database for genome-wide identification of splicing QTLs in human cancer. Nucleic Acids Research 2019, 47(D1): D909-D916;

12．Chang Jiang^#, Zhong Rong^#, Tian Jianbo^#, Li Jiaoyuan^#, …, Wu Chen*, Miao Xiaoping*, Lin Dongxin. Exome-wide analyses identify low-frequency variant in CYP26B1 and additional coding variants associated with esophageal squamous cell carcinoma. Nature Genetics 2018, 50(3): 338-343;

13．Gong Jing^#, Tian Jianbo^#, Lou Jiao, …, Zhong Rong, Chang Jiang, Miao Xiaoping. A polymorphic MYC response element in KBTBD11 influences colorectal cancer risk, especially in interaction with an MYC-regulated SNP rs6983267. Annals of Oncology 2018, 29(3): 632-639;

实验室简介