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W

吴迪

邮          箱:wudi1985@gmail.com

职          称:特聘研究员

办公室地址:

实验室地址:医学部9号楼

个人简介

个人介绍


教育经历

2010-2015 邓迪大学生命科学学院,博士

2007-2010 武汉大学生命科学学院,硕士

2003-2007 武汉大学生命科学学院,学士

工作经历

2024-今 武汉大学泰康医学院(基础医学院) 特聘研究员

2024-今 武汉大学泰康生命医学中心 PI

2015-2024 牛津大学化学院,博士后



科研领域


基于结构质谱和多组学,发现并阐明重要膜蛋白受体的内源性配体及调控机理。

基于蛋白质质谱,研究疾病相关翻译后修饰对蛋白复合物的动态调控。

开发适用于检测单细胞膜蛋白复合物及其信号通路调控的高分辨率质谱新方法。


代表性论文


1. D. Wu, H. Tang, X. Qiu, S. Song, S. Chen, C. V. Robinson Native MS guided lipidomics to define endogenous lipid micro-environments of eukaryotic receptors and transporters Nat. Protoc. 2024 (Featured article)

2. D. Wu *, R. Yan, S. Song, A. K. Swansiger, Y. Li, J. S. Prell, Q. Zhou, C. V. Robinson * (Co-corresponding authorThe complete assembly of human LAT1-4F2hc complex provides insights into its regulation, function and localisation Nat. Commun. 2024, 15, 3711 (Featured article in Editors’ Highlights)

3. Y. Yan, J. Xiao, F. Huang, W. Xian, B. Yu, R. Cheng, H. Wu, X. Lu, X. Wang, W. Huang, Jing Li, G. K. Oyejobi, C. V. Robinson, H. Wu, D. Wu*, X. Liu*, L. Wang*, B. Zhu* (Co-corresponding authorPhage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway Nat. Microbiol. 2024, 9, 1566–1578

4. D. Wu, M. Guo, C. V. Robinson Connecting single nucleotide polymorphisms, glycosylation status and interactions of plasma serine protease inhibitors Chem. 2023, 9, 665-681

5. D. Wu* and C. V. Robinson* (Co-corresponding authorNative top-down mass spectrometry reveals a role for interfacial glycans on therapeutic cytokine and hormone assemblies Angew. Chemie Int. Ed. 2022, 202213170, 1-8. (Cover)

6. D. Wu and C. V. Robinson Understanding glycoprotein structural heterogeneity and interactions: insights from native mass spectrometry

Curr. Opin. Struct. Biol. 2022, 74, 102351.

7. D. Wu and C. V. Robinson Connecting ‘multi-omics’ approaches to endogenous protein complexes Trends in Chem. 2021, 3, 445-455. (Cover)

8. D. Wu, J. Li, W. B. Struwe and C. V. Robinson Probing N-glycoprotein microheterogeneity by lectin affinity purification-mass spectrometry analysis Chem. Sci. 2019, 10, 5146-5155.

9. D. Wu, W. B. Struwe, D. J. Harvey, M. A. J. Ferguson and C. V. Robinson N-glycan microheterogeneity regulates interactions of plasma proteins Proc. Natl. Acad. Sci. 2018, 115, 8763–8768.

完整文章列表

https://scholar.google.com/citations?user=DKqinjAAAAAJ


实验室简介


研究方向 多组学及蛋白质质谱学 邮箱 wudi1985@gmail.com
职称 特聘研究员 办公室地址
实验室地址 医学部9号楼