个人简介

个人介绍

武汉大学医学部常务副部长，中南医院泌尿外科碎石中心主任，武汉大学泌尿外科研究所常务副所长，肿瘤精准诊疗技术与转化医学湖北省工程研究中心常务副主任。兼任中国高等教育学会医学教育专委会常务理事，湖北省医师协会副会长。

荣誉奖励

荣获中华医学会泌尿外科分会金探针奖、湖北省科技进步一等奖，湖北省科学技术推广奖一等奖，广西壮族自治区科学技术进步奖一等奖，国家科学技术进步奖二等奖等奖励。

社会服务

• 中国高等教育学会医学教育专委会常务理事

• 湖北省医师协会副会长

• 中华医学会泌尿外科分会基础学组副组长

• 海峡两岸医药卫生交流协会泌尿分会常委

• 国际尿石症联盟委员、

执教课程

本科生课程：

分子生物学；泌尿男生殖系统外科检查和诊断；泌尿系损伤

研究生课程：临床研究与创新转化；泌尿系疾病基础研究进展；结石病因学

科研领域

目前已分别主持国家自然科学基金资助项目8项、国家863子课题2项、国家新药创制重大计划子课题2项、卫生部行业基金1项。

代表性论文

1． Yangjun Zhang, Xiangyang Yao, Hui Zhou, Xiaoliang Wu, Jianbo Tian, Jin Zeng, Libin Yan, Chen Duan, Haoran Liu, Heng Li, Ke Chen, Zhiquan Hu, Zhangqun Ye, Hua Xu* OncoSplicing: an updated database for clinically relevant alternative splicing in 33 human cancers. Nucleic Acids Research.2021 Sep 23. doi: 10.1093/nar/gkab851.

2． Heng Li, Yucong Zhang, Dong Li, Xin Ma, Kai Xu, Ruihua An, Jiping Qi, Aitao Guo, Zhangqun Ye, Jiumin Liu, Xu Zhang*, Hua Xu*. Androgen Receptor Splice Variant 7 Predicts Shorter Response in Patients with Metastatic Hormone-sensitive Prostate Cancer Receiving Androgen Deprivation Therapy. European Urology. 2021

3． Yangjun Zhang, Xiaoliang Wu, Jingzhen Li, Kui Sun, Heng Li, ------ Zhangqun Ye, Mugen Liu, Hua Xu*. Comprehensive characterization of alternative splicing in renal cell carcinoma. Briefings In Bioinformatics. 2021.

4． Ke Chen, Jin Zeng, Yi Sun, Wei Ouyang, Gan Yu, Hui Zhou, Kefeng Xiao, Lily Wu, Zhiqiang Chen, Zhangqun Ye, Hua Xu*. Junction plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma. Cancer Communications 2021.

5． Haoran Liu, Xiaoqi Yang, Kun Tang, Tao Ye, Chen Duan, e Liu, Yaoliang Deng, Guohua Zeng, Jinchun Xing, Zhangqun Ye, Hua Xu*. Sulforaphane elicits dual therapeutic effects on Renal Inflammatory Injury and crystal deposition in Calcium Oxalate Nephrocalcinosis. Theranostics. 2020; 10(16): 7319-7334.

6． Libin Yan, Beichen Ding, Haoran Liu, Yangjun Zhang, Jin Zeng, -------- Zhangqun Ye, Jinchun Xing, Kefeng Xiao, Lily Wu, Hua Xu*. Inhibition of SMYD2 Suppresses Tumor Progression by Down-regulating microRNA-125b and Attenuates Multi-drug Resistance in Renal Cell Carcinoma. Theranostics. 2019 Oct 22;9(26):8377-8391.

7． Yangjun Zhang, Libin Yan, Jin Zeng, Hui Zhou, Haoran Liu, Gan Yu, Weimin Yao, Ke Chen, Zhangqun Ye, Hua Xu*. Pan-cancer analysis of clinical relevance of alternative splicing events in 31 human cancers. Oncogene. 2019 Aug 7.

8． Zhangqun Ye, Guohua Zeng, Huan Yang, Kun Tang, ---------- Siping Liu, Guoqing Liu, Xun Xu, Wei He, Zhiqiang Chen*, Hua Xu*. Efficacy and Safety of Tamsulosin in Medical Expulsive Therapy for Distal Ureteral Stones with Renal Colic: A Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial. European Urology.73 (2018) 385-391.

9． Heng Li, Zhize Wang, Wei Xiao, Libin Yan, Zhiquan Hu, Hua Xu*, Zhangqun Ye, Xu Zhang. AR-V7 positive prostate cancer: A novel molecular subtype with dramatically worse outcomes of androgen deprivation therapy in newly diagnosed prostate cancer. Modern Pathology. 2018, 31(1): 198-208.

10． Ke Chen, Haibing Xiao, Jin Zeng, Gan Yu, Hui Zhou, ------- Junhui Hu, Wei Guan, Lily Wu, Jiaoti Huang, Qihong Huang, Hua Xu*, Zhangqun Ye. Alternative splicing of EZH2 pre-mRNA by SF3B3 contributes to the tumorigenic potential of renal cancer. Clinical Cancer Research 2017 Jul 1;23(13):3428-3441

Junhui Hu, Wei Guan, Peijun Liu, Jin Dai, Kun Tang, Haibing Xiao, Yuan Qian, Allison C. Sharrow, Lily Wu, Hua Xu*. Endoglin is Essential for the Maintenance of Self-Renewal and Chemoresistance in Renal Cancer Stem Cells. Stem Cell Reports. 2017 Aug;9(2):464-477.

实验室简介