个人简介

个人介绍

钟波，男，1983年12月，教授、博导。

教育经历

2001.9－2005.6 中国地质大学外国语学院 英语专业 学士

2003.2－2005.6 武汉大学生命科学学院 生物科学专业 学士

2005.9－2010.6 武汉大学生命科学学院 细胞生物学 博士

工作经历

2010.7－2013.2 UT MD Anderson Cancer Center 博士后

2013.3－至 今 武汉大学生命科学学院、医学研究院

教育部免疫代谢前沿科学中心，教授

荣誉奖励

2020 顾孝诚讲座奖

2020 美国免疫学家学会“Laboratory Travel Grant”，美国

2017 中国细胞生物学学会青年研究员奖

2015 国家自然科学二等奖（第二完成人）

社会服务

Journal of Cell Biology 编委

Virologica Sinica 编委

Cell Insight 副主编

Frontier in Microbiology 副主编

科研领域

主要从事感染免疫与炎症反应分子机制与靶向治疗的研究，发现了泛素化与去泛素化修饰在调控病毒免疫、炎性疾病与肿瘤发生转移等过程的关键作用，揭示了相关机制，并从概念上证实靶向相关去泛素化酶可以治疗感染、炎症与肿瘤发生转移。发表论文70余篇，以（共）通讯作者发表论文21篇，包括Nat Cancer，Cell Res（3篇），Cell Host Microbe，Adv Sci（3篇），Nat Commun（4篇），JEM，PNAS等。主持多项国际合作、国家和省部级科研项目，包括国家自然科学基金重点项目、科技部重点研发计划项目等。

代表性论文

1. XiongTC#, Wei MC#, Li FX#, Shi M, Gan H, Tang Z, Dong HP, Liuyu T, Gao P,Zhong B*, Zhang ZD*, Lin D*. The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS.Nat Commun, Accepted.

2. An R, Wang P, Guo H, Liuyu T,Zhong B*, Zhang ZD*. USP2 promotes experimental colitis and bacterial infections by inhibiting the proliferation of myeloid cells and remodeling the extracellular matrix network.Cell Insight, 2022, 1(4): 100047. doi: 10.1016/j.cellin.2022.100047.

3. Zhang ZD, Li HX, Gan H, Tang Z, Guo YY, Yao SQ, Liuyu T,Zhong B*, Lin D*. RNF115 inhibits the post-ER trafficking of TLRs and TLRs-mediated immune responses by catalyzing K11-linked ubiquitination of RAB1A and RAB13.Adv Sci, 2022, 9(16): 2105391. doi:10.1002/advs.202105391.

4. Yang W#, Dong HP#, Wang P#, Xu ZG, Xian J, Chen J, Wu H, Lou Y, Lin D*,Zhong B*.IL-36gand IL-36Ra reciprocally regulate colon tumorigenesis by modulating the cell-matrix adhesion network and Wnt signaling.Adv Sci, 2022, 9(10): 2103035. doi:10.1002/advs.202103035.

5. Zhang ZD,Zhong B*.Regulation and function of the cGAS-MITA/STING axis in health and disease.Cell Insight, 2022, 1(1): 100001. doi:10.1016/j.cellin.2021.100001.

6. Wang P#, Yang W#, Guo H, Dong HP, Guo YY, Gan H, Wang Z, Cheng Y, Deng Y, Xie S, Yang X, Lin D*,Zhong B*.IL-36gand IL-36Ra reciprocally regulate NSCLC progression by modulating GSH homeostasis and oxidative stress-induced cell death.Adv Sci, 2021, 8(19): 2101501. doi: 10.1002/advs.202101501.

7. Zhang M#, YangW#,WangP, Deng Y,Dong YT,Liu FF,Huang R, Zhang P, Duan YQ,Liu XD, Lin D*, ChuQ*,ZhongB*.CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer.Nat Commun, 2020,11:6119. Nov 30,doi:10.1038/s41467-020-19973-6.

8. Zhang ZD#, Xiong TC#, Yao SQ, Wei MC, Chen M, Lin D,Zhong B*.RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA.Nat Commun, 2020, 11: 5536. Nov 2, doi: 10.1038/s41467-020-19318-3.

9. Wang XM, Yang C, Zhao Y, Xu Z, Yang W, Wang P, Lin D, Xiong B, Fang J, Dong C,Zhong B*. The deubiquitinase USP25 supports colonic inflammation and bacterial infection and promotes colorectal cancer.Nat Cancer, 2020, 1: 811-825. July 6,doi:10.1038/s43018-020-0089-4.

10. Zhang Q, Tang Z, An R, Ye L,Zhong B*.USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity.Cell Res,2020,30, 914-927. May 26,doi: 10.1038/s41422-020-0341-6.

11. Cai Z, Zhang MX, Tang Z, Zhang Q, Ye J, Xiong TC, Zhang ZD,Zhong B*. USP22promotes IRF3nuclear translocationandantiviral responses by deubiquitinatingthe importin proteinKPNA2.J Exp. Med., 2020,217, 5: e20191174.

12. Li SZ*, Shu QP, Song Y, Zhang HH, Liu Y, Jin BX, Liuyu TZ, Li C, Huang XC, Du RL, Song W*,Zhong B*, Zhang XD*.Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response.Nat Commun,2019, 10(1):3233.

13. Ye L#, Zhang Q#, Liuyu T, Xu Z, Zhang MX, Luo MH, Zeng WB, Zhu Q, Lin D*,Zhong B*.USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA.Plos Pathog, 2019,15(4):e1007680.

14. Zhang MX, Cai Z, Zhang M, Wang XM, Wang Y, Zhao F, Zhou J, Luo MH, Zhu Q, Xu Z, Zeng WB*,Zhong B*, Lin D*. USP20 promotes cellular antiviral responses via deconjugating K48-linked ubiquitination of MITA.J Immunol, 2019, 202(8):2397-2406.

15. Liuyu T, Yu K, Ye L, Zhang Z, Zhang M, Ren Y, Cai Z, Zhu Q, Lin D,Zhong B*,Induction of OTUD4 by viral infection promotes antiviralresponses through deubiquitinating and stabilizing MAVS.Cell Res,2019,29(1):67-79.

16. ZhaoY,WangXM, WangQ, Deng Y, LiK,ZhangM,ZhangQ,ZhouJ, Wang HY, BaiP,RenY,ZhangN,LiW,Cheng Y, Xiao W, Du HN, Cheng X,YinL,FuX,LinD, ZhouQ,ZhongB*, USP2a supports metastasis by tuning TGF-bsignaling.Cell Rep,2018, 22(9):2442-2454.

17. Li K,Zhong B*,Regulation of cellular antiviral signaling by modifications of ubiquitin and ubiquitin-like molecules.Immune Network. 2018,18(1):e4.(Invited review)

18. Lu B#,RenY#,SunX#,HanC,Wang H, ChenY,Peng Q, Cheng Y, Cheng X, Zhu Q, LiW, Li HL, Du HN,ZhongB*, HuangZ*.Induction of INKIT by viral infection negatively regulates antiviral responses through inhibiting phosphorylation of p65 and IRF3.Cell Host Microbe, 2017, 22(1):86-98.e4. (Cover story)

19. Sun H#, Zhang Q#, Jing YY, Zhang M, Wang HY, Cai Z, Liuyu T, Zhang ZD, Xiong TC, Wu Y, Zhu QY, Yao J, Shu HB, Lin D,Zhong B*.USP13 negatively regulates antiviral responses by deubiquitinating STING.Nat Commun. 2017, May 23; 8:15534.10.1038/NCOMMS15534.

20. Zhang M#, Zhang MX#, Zhang Q, Zhu GF, Yuan L,ZhangDE, ZhuQY,YaoJ,Shu HB,ZhongB*.USP18 recruits USP20 to promote innate antiviralresponse through deubiquitinating STING/MITA.Cell Res. 2016,26(12): 1302-1319.

21. Ren Y, Zhao Y, Lin D, Xu X, Zhu Q, Yao J, Shu HB,Zhong B*. The type I interferon-IRF7 axis mediates transcriptional expression ofUsp25gene.J Biol Chem.2016, 291(25): 13206-13215.

22. Lin D, Zhang M, Zhang MX, Ren YJ, Jin J, Zhao Q, Pan Z, Wu M, Shu HB, Dong C,Zhong B*.Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6.Proc Natl Acad Sci U S A.2015112(36):11324-329.

23. Lin D,Zhong B*.Regulation of cellular innate antiviral signaling by ubiquitin modification.Acta Biochim Biophys Sin.2015 47(3):149-155.(Invited Review)

24. Zhong B, Liu XK, Wang XH, Liu XD, Li HX, Darnay BR, Lin X, Sun SC and Dong C*. Ubiquitin-specificprotease 25 regulates TLR4-dependent innate immune response through deubiquitination of TRAF3. (2013).Sci Signal. 6, ra35.

25. Liu XK#, Li HX#,Zhong B#,Blonska M,Gorjestani S, Yan M, Tian Q, Zhang DE, Lin X*and Dong C*. USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. (2013).JExp Med.210, 1575-90. (#Co-first authors)

26. ZhongB, LiuXK, Wang XH, Chang SH, Liu XD, Wang AB, Reynolds JM, and Dong C*. Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25. (2012).Nat Immunol.13, 1110-17.

27. Zhong B, Zhang Y, Tan B, Liu TT, Wang YY and Shu HB*.The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation.(2010).J Immunol.184, 6249-6255.

28. Zhong B, Wang YY and Shu HB*.Regulation of virus-triggered type I interferon signaling bycellular and viral proteins. (2010).Frontier in Biology5, 12-31.

29. Zhong B,ZhangL, LeiCQ, Li Y., Mao AP, Yang Y, Wang YY, Zhang XL and Shu HB*.Theubiquitinligase RNF5regulatesantiviralresponses bymediatingdegradation of theadaptorprotein MITA. (2009).Immunity30, 397-407.

30. Zhong B,Yang Y, Li S, Wang YY, Li Y, Diao FC, Lei CQ, He X, Zhang L, Tien, P and Shu HB*.The adapter protein MITA links virus-sensing receptors to IRF3 transcription factor activation. (2008).Immunity29, 538–550.

31. Zhong B, Tien P and Shu HB*.Innate immune responses: crosstalk of signaling and regulation of gene transcription. (2006).Virology352, 14-21.

实验室简介

实验室现有硕博连读生8名，博士后2名，研究助理1名。