个人简介

个人介绍

张振涛，武汉大学珞珈特聘教授、主任医师、博士生导师，武汉大学泰康生命医学中心PI，湖北省神经精神研究所副所长，武汉大学人民医院神经内一科副主任，主要从事神经退行性疾病的基础和临床研究。主持国家重点研发计划、国家优秀青年科学基金、国家自然科学基金青年和面上项目、湖北省杰出青年科学基金等科研项目，发表科研论文70余篇。

教育经历

1999.09-2004.06 潍坊医学院医学系，本科

2004.09-2007.06 华中科技大学同济医学院，硕士研究生

2007.09-2010.06 华中科技大学同济医学院，博士研究生

工作经历

2010.07－2012.01 武汉大学人民医院神经内科，主治医师

2012.02－2015.01 美国Emory大学，博士后

2015.02－2016.10 美国Emory大学，助理教授

2016.11－2017.10 武汉大学人民医院神经内科，教授，副主任医师

2017.11至今 武汉大学人民医院神经内科，教授，主任医师

荣誉奖励

“百千万人才工程”国家级人选

获国家“有突出贡献中青年专家”称号

中国医师协会“中国杰出青年神经内科医师”奖

武汉大学“朱裕璧医学奖”

武汉市中青年医学骨干人才

社会服务

中华医学会神经内科分会帕金森病和运动障碍学组委员

中国医师协会神经内科医师分会帕金森病和运动障碍学组委员

中国睡眠研究会睡眠生理与药理专委会副主任委员

中华医学会肠外肠内营养学分会第五届委员会“脑健康营养协作组”组员

中国老年学和老年医学学会脑认知与健康分会常务委员

中国老年医学学会认知障碍分会常务委员

湖北省医学会神经病学分会青年委员会副主任委员

湖北省帕金森病与运动障碍病学会副会长

湖北省神经科学学会认知科学专业委员会副主任委员

湖北省神经科学学会青年工作委员会副主任委员

科研领域

本团队的研究方向是神经退行性疾病，重点关注阿尔茨海默病和帕金森病的发病机制和诊疗策略。主要的科研方向包括：1）诱导神经退行性疾病患者脑内tau蛋白、α-突触核蛋白和Aβ异常沉积的分子机制，以及蛋白聚集体在神经元之间播散，诱导神经损伤的分子机制；2）神经突触功能障碍的分子机制；3）神经退行性疾病早期诊断生物标志物的研究；4）神经退行性疾病的新药研发。

代表性论文

1. Pan L^#, Li C^#, Meng L, Tian Y, He M, Yuan X, Zhang G, Zhang Z, Xiong J, Chen G,Zhang Z*. Tau accelerates α-synuclein aggregation and spreading in Parkinson's disease. Brain, 2022, awac171.

2. Kang SS^#, Meng L, Zhang X, Wu Z, Mancieri A, Xie B, Liu X, Weinshenker D, Peng J,Zhang Z*, Ye K*. Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation. Nat Struct Mol Biol, 2022, 29(4):292-305.

3. Zhang G^#, Meng L^#, Wang Z, Peng Q, Chen G, Xiong J,Zhang Z*. Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer's disease. Mol Neurodegener, 2022, 17(1):12.

4. Meng L^#, Zou L, Xiong M, Chen J, Zhang X, Yu T, Li Y, Liu C, Chen G, Wang Z, Ye K,Zhang Z*. A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease. Aging Cell, 2022, 21(5):e13619.

5. Yuan X^#, Yang Y, Liu C, Tian Y, Xia D, Liu Z, Pan L, Xiong M, Xiong J, Meng L, Zhang Z, Ye K, Jiang H,Zhang Z*. Fine Particulate Matter Triggers α-Synuclein Fibrillization and Parkinson-like Neurodegeneration. Mov Disord, 2022, doi: 10.1002/mds.29181.

6. Yan M^#, Xiong M, Dai L, Zhang X, Zha Y, Deng X, Yu Z,Zhang Z*. Cofilin 1 promotes the pathogenicity and transmission of pathological α-synuclein in mouse models of Parkinson’s disease. NPJ Parkinson's Disease, 2022, 8(1):1.

7. Tian Y^#, Pan L, Yuan X, Xiong M, Zhang Z, Meng L, Zheng Y, Bu L, Xu X*,Zhang Z*. 7,8-Dihydroxyflavone ameliorates mitochondrial impairment and motor dysfunction in the α-synuclein 1-103 transgenic mice. Neurobiol Dis, 2022, 169:105736.

8. Xiong M^#, Zou L, Meng L, Zhang X, Tian Y, Zhang G, Yang J, Chen G, Xiong J, Ye K,Zhang Z*. A γ-adducin cleavage fragment induces neurite deficits and synaptic dysfunction in Alzheimer's disease. Prog Neurobiol, 2021, 203:102074.

9. Zhang Z^#, Li XG^#, Wang ZH, Song M, Yu SP, Kang SS, Liu X, Zhang Z, Xie M, Liu GP, Wang JZ*, Ye K*. δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer's disease. Mol Psychiatry, 2021, 26(2):586-603.

10. Zou L^#, Zhang X^#, Xiong M, Meng L, Tian Y, Pan L, Yuan X, Chen G, Wang Z, Bu L, Yao Z, Zhang Z, Ye K,Zhang Z*. Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease. Neurobiol Dis, 2021, 154:105326.

11. Yang J^#, Luo S, Zhang J, Yu T, Fu Z, Zheng Y, Xu X, Liu C, Fan M*,Zhang Z*. Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson's disease. Neurobiol Dis, 2021, 148:105218.

12. Zhang X^#, Zou L^#, Meng L, Xiong M, Pan L, Chen G, Zheng Y, Xiong J, Wang Z, Duong DM, Zhang Z, Cao X, Wang T, Tang L, Ye K,Zhang Z*. Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction. Elife, 2021, 10:e65301.

13. Zhang G^#, Nie S, Zhang Z,Zhang Z*. Longitudinal Change of Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies in Patients with Coronavirus Disease 2019. J Infect Dis, 2020, 222(2):183-188.

14. Zhang Z^#,Kang SS, Liu X, Ahn EH, Zhang Z, He L, Iuvone PM, Duong DM, Seyfried NT, Benskey MJ, Manfredsson FP, Jin L*, Sun YE, Wang JZ*, Ye K*. Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease. Nature Structural & Molecular Biology, 2017, 24(8):632-642.

15. Zhang Z^#, Obianyo O^#, Dall E^#, Du Y, Fu H, Liu X, Kang SS, Song M, Yu SP, Cabrele C, Schubert M, Li X, Wang JZ*, Brandstetter H*, Ye K*. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nature Communications, 2017, 8:14740.

16. Zhang Z^#, Song M, Liu X, Su Kang S, Duong DM, Seyfried NT, Cao X, Cheng L, Sun YE*, Ping Yu S, Jia J*, Levey AI, Ye K*. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nature Communications, 2015, 6:8762.

17. Zhang Z^#, Song M, Liu X, Kang SS, Kwon IS, Duong DM, Seyfried NT, Hu WT, Liu Z, Wang JZ, Cheng L*, Sun YE, Yu SP, Levey AI, Ye K*. Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease. Nature Medicine, 2014, 20, 1254-1262.

18. Zhang Z^#, Liu X^#, Schroeder JP, Chan CB, Song M, Yu SP, Weinshenker D, Ye K*. 7, 8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s disease. Neuropsychopharmacology, 2014, 39, 638-650.

实验室简介