个人简介

个人介绍

张振涛，武汉大学珞珈特聘教授、主任医师、博士生导师，武汉大学泰康生命医学中心PI，湖北省神经精神研究所副所长，武汉大学人民医院神经内一科副主任，主要从事神经退行性疾病的基础和临床研究。主持国家重点研发计划、国家优秀青年科学基金、国家自然科学基金青年和面上项目、湖北省杰出青年科学基金等科研项目，发表科研论文70余篇。

教育经历

1999.09-2004.06 潍坊医学院医学系，本科

2004.09-2007.06 华中科技大学同济医学院，硕士研究生

2007.09-2010.06 华中科技大学同济医学院，博士研究生

工作经历

2010.07－2012.01 武汉大学人民医院神经内科，主治医师

2012.02－2015.01 美国Emory大学，博士后

2015.02－2016.10 美国Emory大学，助理教授

2016.11－2017.10 武汉大学人民医院神经内科，教授，副主任医师

2017.11至今 武汉大学人民医院神经内科，教授，主任医师

荣誉奖励

获国家“有突出贡献中青年专家”称号

中国医师协会“中国杰出青年神经内科医师”奖

武汉大学“朱裕璧医学奖”

武汉市中青年医学骨干人才

社会服务

中华医学会神经内科分会帕金森病和运动障碍学组委员

中国医师协会神经内科医师分会帕金森病和运动障碍学组委员

中国睡眠研究会睡眠生理与药理专委会副主任委员

中华医学会肠外肠内营养学分会第五届委员会“脑健康营养协作组”组员

中国老年学和老年医学学会脑认知与健康分会常务委员

中国老年医学学会认知障碍分会常务委员

湖北省医学会神经病学分会青年委员会副主任委员

湖北省帕金森病与运动障碍病学会副会长

湖北省神经科学学会认知科学专业委员会副主任委员

湖北省神经科学学会青年工作委员会副主任委员

科研领域

本团队的研究方向是神经退行性疾病，重点关注阿尔茨海默病和帕金森病的发病机制和诊疗策略。主要的科研方向包括：1）诱导神经退行性疾病患者脑内tau蛋白、α-突触核蛋白和Aβ异常沉积的分子机制，以及蛋白聚集体在神经元之间播散，诱导神经损伤的分子机制；2）神经突触功能障碍的分子机制；3）神经退行性疾病早期诊断生物标志物的研究；4）神经退行性疾病的新药研发。

代表性论文

1. Pan L^#, Li C^#, Meng L, Tian Y, He M, Yuan X, Zhang G, Zhang Z, Xiong J, Chen G,Zhang Z*. Tau accelerates α-synuclein aggregation and spreading in Parkinson's disease. Brain, 2022, awac171.

2. Kang SS^#, Meng L, Zhang X, Wu Z, Mancieri A, Xie B, Liu X, Weinshenker D, Peng J,Zhang Z*, Ye K*. Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation. Nat Struct Mol Biol, 2022, 29(4):292-305.

3. Zhang G^#, Meng L^#, Wang Z, Peng Q, Chen G, Xiong J,Zhang Z*. Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer's disease. Mol Neurodegener, 2022, 17(1):12.

4. Meng L^#, Zou L, Xiong M, Chen J, Zhang X, Yu T, Li Y, Liu C, Chen G, Wang Z, Ye K,Zhang Z*. A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease. Aging Cell, 2022, 21(5):e13619.

5. Yuan X^#, Yang Y, Liu C, Tian Y, Xia D, Liu Z, Pan L, Xiong M, Xiong J, Meng L, Zhang Z, Ye K, Jiang H,Zhang Z*. Fine Particulate Matter Triggers α-Synuclein Fibrillization and Parkinson-like Neurodegeneration. Mov Disord, 2022, doi: 10.1002/mds.29181.

6. Yan M^#, Xiong M, Dai L, Zhang X, Zha Y, Deng X, Yu Z,Zhang Z*. Cofilin 1 promotes the pathogenicity and transmission of pathological α-synuclein in mouse models of Parkinson’s disease. NPJ Parkinson's Disease, 2022, 8(1):1.

7. Tian Y^#, Pan L, Yuan X, Xiong M, Zhang Z, Meng L, Zheng Y, Bu L, Xu X*,Zhang Z*. 7,8-Dihydroxyflavone ameliorates mitochondrial impairment and motor dysfunction in the α-synuclein 1-103 transgenic mice. Neurobiol Dis, 2022, 169:105736.

8. Xiong M^#, Zou L, Meng L, Zhang X, Tian Y, Zhang G, Yang J, Chen G, Xiong J, Ye K,Zhang Z*. A γ-adducin cleavage fragment induces neurite deficits and synaptic dysfunction in Alzheimer's disease. Prog Neurobiol, 2021, 203:102074.

9. Zhang Z^#, Li XG^#, Wang ZH, Song M, Yu SP, Kang SS, Liu X, Zhang Z, Xie M, Liu GP, Wang JZ*, Ye K*. δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer's disease. Mol Psychiatry, 2021, 26(2):586-603.

10. Zou L^#, Zhang X^#, Xiong M, Meng L, Tian Y, Pan L, Yuan X, Chen G, Wang Z, Bu L, Yao Z, Zhang Z, Ye K,Zhang Z*. Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease. Neurobiol Dis, 2021, 154:105326.

11. Yang J^#, Luo S, Zhang J, Yu T, Fu Z, Zheng Y, Xu X, Liu C, Fan M*,Zhang Z*. Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson's disease. Neurobiol Dis, 2021, 148:105218.

12. Zhang X^#, Zou L^#, Meng L, Xiong M, Pan L, Chen G, Zheng Y, Xiong J, Wang Z, Duong DM, Zhang Z, Cao X, Wang T, Tang L, Ye K,Zhang Z*. Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction. Elife, 2021, 10:e65301.

13. Zhang G^#, Nie S, Zhang Z,Zhang Z*. Longitudinal Change of Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies in Patients with Coronavirus Disease 2019. J Infect Dis, 2020, 222(2):183-188.

14. Zhang Z^#,Kang SS, Liu X, Ahn EH, Zhang Z, He L, Iuvone PM, Duong DM, Seyfried NT, Benskey MJ, Manfredsson FP, Jin L*, Sun YE, Wang JZ*, Ye K*. Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease. Nature Structural & Molecular Biology, 2017, 24(8):632-642.

15. Zhang Z^#, Obianyo O^#, Dall E^#, Du Y, Fu H, Liu X, Kang SS, Song M, Yu SP, Cabrele C, Schubert M, Li X, Wang JZ*, Brandstetter H*, Ye K*. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nature Communications, 2017, 8:14740.

16. Zhang Z^#, Song M, Liu X, Su Kang S, Duong DM, Seyfried NT, Cao X, Cheng L, Sun YE*, Ping Yu S, Jia J*, Levey AI, Ye K*. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nature Communications, 2015, 6:8762.

17. Zhang Z^#, Song M, Liu X, Kang SS, Kwon IS, Duong DM, Seyfried NT, Hu WT, Liu Z, Wang JZ, Cheng L*, Sun YE, Yu SP, Levey AI, Ye K*. Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease. Nature Medicine, 2014, 20, 1254-1262.

18. Zhang Z^#, Liu X^#, Schroeder JP, Chan CB, Song M, Yu SP, Weinshenker D, Ye K*. 7, 8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s disease. Neuropsychopharmacology, 2014, 39, 638-650.

实验室简介