个人简介

个人介绍

近五年来，在微生物来源抗感染天然活性分子的筛选方法建立、结构鉴定、活性研究及作用靶点确证等方面取得了系列研究成果。目前，已发表SCI论文21篇，其中作为第一作者或共同第一作者发表研究论文14篇，包括Science1篇、Journal of Clinical Investigation1篇、Organic Letters4篇，并在海洋天然产物药用价值开发方面申请2项美国专利，一项已授权。成功发现了抗真菌化合物Turbinmicin，发表于Science杂志，工作相关研究成果被国内外80余家媒体报道，并被Science和Nature Reviews DrugDiscovery等杂志重点刊文评论。

教育经历

2003.9-2007.6 吉林大学药学院，学士

2007.9-2012.6 中国科学院微生物研究所，博士

工作经历

2012.7-2013.3中国科学院微生物研究所，助理研究员

2013.4-2014.4加拿大曼尼托巴大学化学学院，博士后

2014.5-2015.5美国威斯康星大学麦迪逊分校药学院，博士后

2015.5-2021.5美国威斯康星大学麦迪逊分校药学院，助理科学家

2021.7至今 武汉大学大学药学院，教授，博士生导师；武汉大学泰康生命医学中心PI；武汉大学中南医院 特聘教授

荣誉奖励

科研领域

1.利用多组学技术开展微生物活性天然代谢产物的研究，从中发现新型抗感染药物的先导化合物

2.高活性抗感染分子的活性评价及作用机制研究

3.研究高活性抗感染天然产物的生物合成途径

4.高活性抗感染天然产物结构改造和构效关系

代表性论文

1. Zhang, F.;^#Zhao, M.;^#Braun, D. R.; Ericksen, S. S.; Piotrowski, J. S.; Nelson, J.; Peng, J.; Ananiev, G. E.; Chanana, S.; Barns, K.; Fossen, J.; Sanchez, H.; Chevrette, M. G.; Guzei, I. A., Zhao, C.; Guo, L.; Tang, W.; Currie, C. R.; Rajski, S. R.; Audhya, A.; Andes, D. R.*; Bugni, T. S.* A marine microbiome antifungal targets urgent-threat drug-resistant fungi.Science2020,370, 974–978.

2. Zhao, M.;^#Zhang, F.;^#Zarnowski, R.; Barns, K.; Jones, R. Fossen, J.; Sanchez, H.; Rajski, S. R.; Audhya, A.; Bugni, T. S.*; Andes, D. R.* Turbinmicin inhibitsCandidabiofilm growth by disrupting fungal vesicle-mediated trafficking.J. Clin. Invest.2021,131, e145123.

3. Zhang, F.; Ramos Alvarenga, R. F.; Throckmorton, K.; Chanana, S.; Braun, D. R.; Fossen, J.; Zhao, M.; McCrone, S.; Harper, M. K.; Rajski, S. R.; Rose, W. E.; Andes, D. R.; Thomas, M. G.; Bugni, T. S. * Genome Mining and Metabolomics Unveil Pseudonochelin, an Siderophore Containing 5-Aminosalicylate from a Marine-DerivedPseudonocardiasp. Bacterium.Org. Lett.2022, 24, 3998–4002.

4. Zhang, F.; Wyche, T. P.; Zhu, Y.; Braun, D. R.; Yan, J. –X.; Chanana, S.; Ge, Y.; Guzei, I. A.; Chevrette, M. G.; Currie, C. R.;, Thomas, M. G.; Rajski, S. R.; Bugni, T. S.* MS-derived isotopic fine structure reveals forazoline A as a thioketone-containing marine-derived natural product.Org. Lett.2020,22, 1275–1279.

5. Zhang, F.; Braun, D. R.; Chanana, S.; Rajski, S. R.; Bugni, T. S.* Phallusialides A-E, pyrrole-derived alkaloids discovered from a marine-derivedMicromonosporasp. bacterium using MS-based metabolomics approaches.J. Nat. Prod.2019,82, 3432–3439.

6. Zhang, F.; Braun, D. R.; Rajski, S. R.; DeMaria, D.; Bugni, T. S.* Enhypyrazinones A and B, pyrazinone natural products from a marine-derived myxobacteriumEnhygromyxasp.Mar. Drugs.2019,17, 698.

7. Zhang, F.; Braun, D. R.; Ananiev, G. E.; Hoffmann, F. M.; Tsai, I. W.; Rajski, S. R.; Bugni, T. S.* Biemamides A-E, inhibitors of the TGF-β pathway that block the epithelial to mesenchymal transition.Org. Lett.2018,20, 5529–5532.

8. Zhang, F.; Barns, K.; Hoffmann, F. M.; Braun, D. R.; Andes, D. R.; Bugni, T. S.* Thalassosamide, a siderophore discovered from the marine-derived bacteriumThalassospira profundimaris.J. Nat. Prod.2017,80, 2551–2555.

9. Zhang, F.; Adnani, N.; Vazquez-Rivera, E.; Braun, D. R.; Tonelli, M.; Andes, D. R.; Bugni, T. S.* Application of 3D NMR for structure determination of peptide natural products. J. Org. Chem.2015,80, 8713–8719.

10. Ren, J.;^#Zhang, F.;^#Liu, X.;Li, L.;Liu, G.; Liu, X.; Che, Y.* Neoectrolide A, a new oxaphenalenone spiroketal from the fungusNeonectriasp. Org.Lett.2012,24, 6226–6229.

11. Zhang, F.; Li, L.; Niu, S.; Si, Y.;Guo, L.;Jiang, X.;Che, Y.*A thiopyranchromenone and other chromone derivatives from an endolichenic fungus,Preussia africana.J. Nat. Prod.2012,75, 230–237.

12. Zhang, F.;^#Ding, G.;^#Li, L.;Cai, X.;Si, Y.;Guo, L.;Che, Y.*Isolation, antimicrobial activity, and absolute configuration of the furylidene tetronic acid core of pestalotic acids A–G.Org. Biomol. Chem.2012,10, 5307–5314.

13. Ding, G.;^#Zhang, F.;^#Chen, H.; Guo, L.; Zou, Z.; Che, Y.* Pestaloquinols A and B, isoprenylated epoxyquinols fromPestalotiopsissp.J.Nat.Prod.2011,74,286–291.

14. Zhang, F.; Liu, S.; Lu, X.; Guo, L.; Zhang, H.; Che, Y.* Allenyl and allkynyl phenyl ethers from the endolichenic fungusNeurospora terricola.J.Nat.Prod.2009,72,1782–1785.

15. Schorn, M. A.; Stefan, V.; [et al, includingZhang, F.] A community resource for paired genomic and metabolomic data mining.Nat Chem Biol.2021,17, 363–368.

16. Vinnik, V.;Zhang, F.; Park, H.; Cook, T.; Throckmorton, K.; Pfleger, B.; Bugni, T.; Thomas, M.* Structural and biosynthetic analysis of the fabrubactins, unusual siderophores from Agrobacterium fabrum strain C58.ACS Chem. Biol.2021, 16, 125–135.

17. Chanana, S.; Thomas, C. S.;Zhang, F.; Rajski, S. R.; Bugni T. S.*hcapca: Automated Hierarchical Clustering and Principal Component Analysis of large metabolomic datasets in R.Metabolites2020, 10, 297.

18. Chevrette, M. G.; Carlson, C. M.; Ortega, H. E.; Thomas, C.; Ananiev, G. E.; Barns, K. J.; Book, A. J.; Cagnazzo, J.; Carlos, C.; Flanigan, W.; Grubbs, K. J.; Horn, H. A.; Hoffmann, F. M.; Klassen, J. L.; Knack, J. J.; Lewin, G. R.; McDonald, B. R.; Muller, L.; Melo, W. G. P.; Pinto-Tomás, A. A.; Schmitz, A.; Wendt-Pienkowski, E.; Wildman, S.; Zhao, M.;Zhang, F.; Bugni, T. S.; Andes, D. R.; Pupo, M. T.; Currie C. R.* The antimicrobial potential ofStreptomycesfrom insect microbiomes.Nat. Commun.2019,10, 516.

19. Adnani, N.; Chevrette, M. G.; Adibhatla, S. N.;Zhang, F.; Yu, Q.; Braun, D. R.; Nelson, J.; Simpkins, S. W.; McDonald, B. R.; Myers, C. L.; Piotrowski, J. S.; Thompson, C. J.; Currie, C. R.; Li, L.; Rajski, S. R.; Bugni, T. S.* Coculture of marine invertebrate-associated bacteria and interdisciplinary technologies enable biosynthesis and discovery of a new antibiotic, keyicin.ACS Chem. Biol.2017,12, 3093–3102.

20. Xu, X.; Liu, L.;Zhang, F.; Wang, W.; Li, J.; Guo, L.; Che, Y.*; Liu, G.* Identification of the first diphenyl ether gene cluster for pestheic acid biosynthesis in plant endophytePestalotiopsis fici.ChemBioChem2014, 15, 284–292.

21. Li, E.;Zhang, F.; Niu, S.; Liu, X.; Liu, G.; Che, Y.* A spiro[chroman-3,7'-isochromene]- 4,6'(8H')-dione from theCordyceps-Colonizing fungusFimetariellasp.Org.Lett.2012,14, 3320–3323.

实验室简介