个人简介

蓝柯，教授、博导，国家杰出青年基金获得者。2006年8月起任中科院上海巴斯德所研究员；2011年-2016年担任中科院上海巴斯德所副所长；2017年1月至今担任病毒学国家重点实验室主任、武汉大学生命科学学院教授；2020年5月至今担任武汉大学动物生物安全三级实验室/动物实验中心主任；2021年4月至今担任武汉大学疫苗研究院院长。

教育经历

1989.09-1994.07重庆医科大学临床医学专业，获医学学士学位

1995.09-1998.07重庆医科大学病理生理学专业，获医学硕士学位

1998.09-2001.07中南大学湘雅医学院病理生理学专业，获医学博士学

工作经历

2002.06-2006.08 美国宾夕法尼亚大学医学院，博士后

2006.08-2016.12 中国科学院上海巴斯德研究所研究员，博士生导师

2011.01-2016.12 中国科学院上海巴斯德研究所副所长，纪委书记

2017.01-至今武汉大学病毒学国家重点实验室主任，生命科学学院教授、博士生导师

2020.05-至今武汉大学动物生物安全三级实验室/动物实验中心主任

2021.04-至今 武汉大学疫苗研究院院长

荣誉奖励

2006：美国白血病和淋巴瘤学会Special Fellow Award；

2012：药明康德生命化学研究奖；

2015：上海市领军人才；

2015：上海市先进工作者；

2020：武汉大学“珞珈抗疫”十大先锋人物；

2020：湖北省抗击新冠肺炎疫情先进个人；

2020：武汉大学“我心目中的好导师”；

2021：湖北省高等学校优秀共产党员；

2021：武汉大学优秀共产党员；

2022：湖北省科协系统先进工作者；

社会服务

Cell Insight 执行主编

Journal of Virology编委；2015-2020

Viruses编委；

Journal of Medical Virology副主编；

Virologica Sinica副主编；

Science Bulletin副主编；

中国微生物学会病毒专业委员会副主任委员；

湖北省生物工程学会理事长；

国家认可委生物安全专业委员会委员；

国家病原微生物实验室生物安全专家委员会委员

科研领域

主要从事肿瘤疱疹病毒、重要新发病毒的感染及致病机理研究，在卡波氏肉瘤病毒（KSHV）、新冠病毒（SARS-CoV-2）等方面做出了系统性、原创性的研究工作，在Nature、N Engl J Med、PLoS Pathogens、Emerg Microbes Infect、Journal of Virology、Cell Host Microbe、PNAS、Science Advances、Cell Research、Cancer Research等学术期刊发表论文120余篇。

代表性论文

1. HanCY#,ZhangD,GuiCW,HuangL,ChangSJ,DongLH,BaiL,WuSW,LanK*.KSHV RTA antagonizes SMC5/6 complex-induced viral chromatin compaction by hijacking the ubiquitin-proteasome system.PLoS Pathog(6.823).2022 Aug 1;18(8):e1010744.doi: 10.1371/journal.ppat.1010744

2. DongLH#,DongJZ#,XiangM,LeiP,LiZX,ZhangF,SunXY,NiuDP,BaiL*,LanK*.NDRG1 facilitates lyticreplication of Kaposi's sarcoma-associated herpesvirus by maintaining the stability of the KSHV helicase.PLoS Pathog.2021 Jun 2;17(6):e1009645.doi: 10.1371/journal.ppat.1009645. eCollection 2021 Jun

3. YanH# ,JiaoHW# ,LiuQY,ZhangZ,XiongQ,WangBJ,WangX,GuoM,WangLF,LanK*,ChenY*,ZhaoHB*.ACE2 receptor usage reveals variation insusceptibility to SARS-CoV and SARS-CoV-2 infection among bat species.Nat Ecol Evol. 2021 Mar 1.doi: 10.1038/s41559-021-01407-1

4. Bai L#, Zhao YL#, Dong JZ, Liang SM, Guo M, Liu XJ, Wang X, Huang ZX, Sun XY, Zhang Z, Dong LH, Liu QY, Zheng YC, Niu DP, Xiang M, Song K, Ye JJ, Zheng WC, Tang ZD, Tang ML, Zhou Y, Shen C, Dai M, Zhou L, Chen Y, Yan H,Lan K*, Xu K*.Coinfection with influenza A virus enhances SARS-CoV-2 infectivity.Cell Research.2021 Apr;31(4):395-403.doi: 10.1038/s41422-021-00473-1

5. Wang DH#, Jiang A#, Feng JP#,LiGN#,GuoD#,Muhammad Sajid,WuK,ZhangQH,Yann Ponty,Sebastian Will,LiuFY,YuXH,SPLi,LiuQY,YangXL,GuoM,LiXQ,ChenMZ,ShiZL,LanK*,ChenY*,ZhouY*.The SARS-CoV-2 Subgenome Landscape and its Novel Regulatory Features.Mol Cell.Published:March 03, 2021DOI:https://doi.org/10.1016/j.molcel.2021.02.036

6. WeiXQ,DongJZ,ChengCC,JiMJ,YuL,LuoSQ,WuSW,BaiL,LanK*.Host RAB11FIP5 protein inhibits the release of Kaposi’s sarcoma-associated herpesvirus particles by promoting lysosomal degradation of ORF45.PLoS Pathog.2020;16(12):e1009099.doi:10.1371/journal.ppat.1009099. eCollection

7. Liu Y#, Ning Z#*, Chen Y#*, Guo M#, Liu Y, Gali NK, Sun L, Duan Y, Cai J, Westerdahl D, Liu X, Xu K, Ho KF*, Kan H*, Fu Q*,Lan K*. Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals.Nature. 2020;582(7813):557-560.

8. Liu W#, Zhang Q#, Chen J#, Xiang R, Song H, Shu S, Chen L, Liang L, Zhou J, You L, Wu P, Zhang B, Lu Y, Xia L, Huang L, Yang Y, Liu F, Semple MG, Cowling BJ,Lan K*, Sun Z*, Yu H*, Liu Y*. Detection of Covid-19 in Children in Early January 2020 in Wuhan,China.N Engl J Med. 2020;382(14):1370-1371.

9. Chen L#, Liu W#, Zhang Q#, Xu K, Ye G, Wu W, Sun Z, Liu F, Wu K, Zhong B, Mei Y, Zhang W, Chen Y, Li Y, Shi M,Lan K*, Liu Y*. RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak.Emerg Microbes Infect. 2020;9(1):313-319.

10. Bai L#, Dong J, Liu Z, Rao Y, Feng P*,Lan K*. Viperin catalyzes methionine oxidation to promote protein expression and function of helicases.Sci Adv,2019 Aug 28;5(8):eaax1031

11. Zhang F, Liang D, Lin X, Zou Z, Sun R, Wang X, Liang X, Kaye KM,Lan K*. NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA.PLoS Pathog. 2019;15(2):e1007628

12. Wei X#, Bai L#,Dong L,Liu H,Zhou Z,Xing P, Wu S,Lan K*. NCOA2 promotes lytic reactivation of Kaposi’s sarcoma-associated herpesvirus by enhancing the expression of the master switch protein RTA.PLoS Pathogens,2019;15(11):e1008160.

13. Yuan F#, Gao ZQ, Majerciak V, Bai L, Hu ML, Lin XX, Zheng ZM*, Dong YH*,Lan K*. The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function.PLoS Pathog. 2018;14(8):e1007232

14. Li G#, Zhu Y, Shao D, Chang H, Zhang X, Zhou D, Gao Y,Lan K*, Deng Q*. Recombinant covalently closed circular DNA of hepatitis B virus induces long-term viral persistence with chronic hepatitis in a mouse model.Hepatology. 2018;67(1):56-70.

15. Wang X#, Zou Z, Deng Z, Liang D, Zhou X, Sun R,Lan K*. Male hormones activate EphA2 to facilitate Kaposi's sarcoma-associated herpesvirus infection: Implications for gender disparity in Kaposi's sarcoma.PLoS Pathog. 2017;13(9):e1006580.

16. Sun R#, Tan X, Wang X, Wang X, Yang L, Robertson ES,Lan K*. Epigenetic Landscape of Kaposi's Sarcoma-Associated Herpesvirus Genome in Classic Kaposi's Sarcoma Tissues.PLoS Pathog. 2017;13(1):e1006167

17. Li S#, Hu H, He Z, Liang D, Sun R,Lan K*. Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway.PLoS Pathog. 2016;12(10):e1005900

18. Jia B#, Guo M, Li G, Yu D, Zhang X,Lan K*, Deng Q*. Hepatitis B virus core protein sensitizes hepatocytes to tumor necrosis factor-induced apoptosis by suppression of the phosphorylation of mitogen-activated protein kinase kinase 7.J Virol. 2015 ;89(4):2041-51.

19. Liang D#, Hu H, Li S, Dong J, Wang X, Wang Y, He L, He Z, Gao Y, Gao S,Lan K*. Oncogenic Herpesvirus KSHV Hijacks BMP-Smad1-Id Signaling to Promote Tumorigenesis.PLoS Pathog. 2014;10(7):e1004253.

20. Qi Z#, Li G, Hu H, Yang C, Zhang X, Leng Q, Xie Y, Yu D, Zhang X, Gao Y,Lan K*, Deng Q*. Recombinant Covalently Closed Circular Hepatitis B Virus DNA Induces Prolonged Viral Persistence in Immunocompetent Mice.J Virol. 2014;88(14):8045-56

21. Sun R#, Liang D, Gao Y,Lan K*. Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Interacts with Host KAP1 To Facilitate Establishment of Viral Latency.J Virol. 2014;88(13):7331-7344.

22. Wang Z#, Zhu K, Bai W, Jia B, Hu H, Zhou D, Zhang X, Zhang X, Xie Y, Bourgine MM, Michel ML,Lan K*, Deng Q*. Adenoviral delivery of recombinant hepatitis B virus expressing foreign antigenic epitopes for immunotherapy of persistent viral infection.J Virol. 2014;88(5):3004-15.

23. Qi Z#, Li G, Hu H, Yang C, Zhang X, Leng Q, Xie Y, Yu D, Zhang X, Gao Y,Lan K*, Deng Q*. Recombinant Covalently Closed Circular Hepatitis B Virus DNA Induces Prolonged Viral Persistence in Immunocompetent Mice.J Virol. 2014;88(14):8045-56.

24. Lin X#, Li X, Liang D,Lan K*. MicroRNAs and unusual small RNAs discovered in Kaposi's sarcoma-associated herpesvirusvirions.J Virol. 2012;86(23): 12717-30.

25. Jin Y#, He Z, Liang D, Zhang Q, Zhang H, Deng Q, Robertson ES,Lan K*. Carboxyl-Terminal Amino Acids 1052 to 1082 of the Latency-Associated Nuclear Antigen (LANA) Interact with RBP-Jκ and Are Responsible for LANA-Mediated RTA Repression.J Virol. 2012;86(9):4956-69

26. Liu Y#, Sun R, Lin X, Liang D, Deng Q,Lan K*. Kaposi's sarcoma-associated herpesvirus-encoded microRNA miR-K12-11 attenuates transforming growth factor beta signaling through suppression of SMAD5.J Virol. 2012; 86(3):1372-81.

27. Li X#, Liang D, Lin X, Robertson ES,Lan K*. Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65.J Virol.2011;85(17):8606-15.

28. Liang D#, Gao Y, Lin X, He Z, Zhao Q, Deng Q,Lan K*. A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKKε.Cell Res. 2011;21(5):793-806.

29. He Z, Liu Y, Liang D, Wang Z, Robertson ES,Lan K*. Cellular corepressor TLE2 inhib its replication-and-transcription- activator-mediated transactivation and lytic reactivatin of Kaposi's sarcoma-associated herpesvirus.J Virol.2010;84(4):2047-62.

实验室简介