Report Summary:

The human genome has extensively transcribed to produce a large number of non coding RNA molecules, such as IncRNA, circRNA, eRNA, and uaRNA, and plays a crucial regulatory role in fate determining processes such as cell development, differentiation, and carcinogenesis. Unlike mRNA, non coding RNAs often require the formation of complex higher-order structures and interact with other RNA molecules with the help of RNA binding proteins to regulate genetic information transmission processes such as transcription, splicing, and translation. The reporter is dedicated to studying the molecular mechanisms of non coding RNA regulation of transcription and the structural basis for its implementation. We have recently created new RNA functional genomics technologies such as RIC seq, vRIC seq, and LACE seq to address the challenges in studying advanced structures and targets of non coding RNA in situ. We have unexpectedly discovered new mechanisms, patterns, and guidelines for non coding RNA regulation of transcription. In this report, I will share with you the hardships and unexpected joys of these research findings.

Reported by:

Xue Yuanchao is a researcher of Institute of Biophysics, Chinese Academy of Sciences, winner of National Science Fund for Distinguished Young Scholars, overseas high-level talent plan, and chief scientist of national key research and development projects. He is mainly engaged in the research on the functional mechanism of non coding RNA and the research and development of related technologies. In recent years, he has published more than 40 papers in Nature, Nat Cell Biol, Mol Cell and other journals, and has won scientific honors and awards such as the Innovation and Breakthrough Award of China Resources Union Medical College, the Wuming Kant Biochemistry Research Fellow Award, and the Outstanding Tutor Award of the Chinese Academy of Sciences.