1. Rapid isolation and detection of extracellular vesicles.2. Biogenesis mechanism and biological function of extracellular vesicles.3. Clinical transformation of extracellular vesicles.
Maintenance of genome stability is essential for the faithful transmission of genetic materials to daughter cells. Eukaryotic cells integrate an efficient DNA damage response network with accurate chromosome segregation mechanisms to preserve genome stability. Deficiency in DNA repair or chromosome segregation often causes mutation, chromosome breakage, aneuploidy, and genome instability, leading to cancer and other human diseases.
Over the past decades, Prof. Zixin Deng has developed efficient gene-editing and BGC direct-cloning and screening systems for several important antibiotics producers, and has cloned more than 100 BGCs of important natural products. Moreover, his research team has designed and generated more than 10 artificial hybrid antibiotics with improved activities. Most importantly, Prof. Deng has revealed the first phosphonothioation modification on DNA backbone, opening up a fascinating new research field of microbial epigenetics.
he joined Wuhan University as a full professor. He developed the liquid metal growth system to manufacture advanced materials with atomic precision.
1) Microbial energy metabolism and biosynthesis. Energy metabolism is a fundamental process for all living organisms. Previous studies revealed a novel mechanism of oxygenic photosynthesis driven by far-red light in cyanobacteria, which is of great significance for enhancing energy utilization and biomass production. Current research interests include microbial energy harvesting and conversion, and construction of microbial systems to synthesize important bioactive molecules.
The coordinated function of various organs in the body largely depends on intercellular communication, which occurs constantly through various mechanisms. Therefore, deciphering the language of intercellular communication is a crucial aspect of understanding the integral functionality of cells. This challenge is not only important but highly intriguing. Our research begins with a focus on metabolic diseases, primarily targeting the liver, adipose tissue, pancreas, and related immune cells. We employ extracellular vesicles
