Report Summary:

In mammals, skeletal muscle stem cells (MuSCs) are essential for injury induced muscle regeneration. In undamaged adult muscles, MuSC is mostly in a stationary state; After injury, they are activated and re-enter the cell cycle, becoming proliferating myoblasts that can differentiate and fuse to repair damaged muscle tissue. Professor Wu's series of work identified two key checkpoints in the early activation process of MuSC before re entering the cell cycle; Interruption of any checkpoint will prevent MuSCs from re entering the cell cycle, leading to complete failure of injury induced muscle regeneration. In this report, Professor Wu will briefly summarize these findings.

Report Summary:

In mammals, skeletal muscle stem cells (MuSCs) are essential for injury induced muscle regeneration. In undamaged adult muscles, MuSC is mostly in a stationary state; After injury, they are activated and re-enter the cell cycle, becoming proliferating myoblasts that can differentiate and fuse to repair damaged muscle tissue. Professor Wu's series of work identified two key checkpoints in the early activation process of MuSC before re entering the cell cycle; Interruption of any checkpoint will prevent MuSCs from re entering the cell cycle, leading to complete failure of injury induced muscle regeneration. In this report, Professor Wu will briefly summarize these findings.