Biography

Prof. Yu, MD, Ph.D., is first class chief physician, third class professor, and doctoral supervisor. He is vice president of Renmin Hospital of Wuhan University, vice president of Cardiovascular Hospital of Renmin Hospital of Wuhan University, and executive director of Hubei Key Laboratory of Autonomic Nervous System Modulation. Prof. Yu has obtained 6 national honors including the National Ten Thousand Talents Plan-Outstanding Young Talents and the National Outstanding Young and Mid-aged Expert by the National Health Commission.

Professor Yu experts in clinical and basic innovative translational research on cardiovascular diseases. He has presided over 17 project grants including the National High-Level Talents Special Support Program and the National Natural Science Foundation of China, etc. He has published more than 70 peer-reviewed papers in Circulation, J Am Coll Cardiol, Adv Mater, Nat Commun, Adv Funct Mater, Nano Energy, Adv Sci, JACC Cardiovasc Interv, etc, which have been cited more than 5,000 times by Cell, JAMA, Nat Rev Cardiol, Nature Reviews Materials and other journals. Professor Yu has won more than 20 international, national, and provincial Science and Technology Progress Awards, including the American College of Cardiology Cardiac Interventional "Youth Achievement Award" and 2 Provincial Science and Technology Progress first prizes.

Research

1. Innovative research and clinical technology development for cardiovascular diseases
2. Neuroimmune metabolism mechanism research of cardiovascular disease

Representative  Publications

1. Yu L(#), Scherlag BJ, Dormer K, Nguyen KT, Pope C, Fung KM, Sunny Po(^*).Autonomic denervation with magnetic nanoparticles. Circulation. 2010; 122（25）:2653~2659（IF39.918）
2. Zhang L(#), Guo F(#), Xu S, Deng Q, Xie M, Sun J, Kwok RTK, Lam JWY, Deng H(^*), Jiang H(^*), Yu L(^*), Tang BZ(^*). AIEgen-based Covalent Organic Frameworks for Preventing Malignant Ventricular Arrhythmias Via Local Hyperthermia Therapy. Adv Mater. 2023 Aug 2:e2304620.（IF32.086）
3.Yang Y(#), Wang J, Huang W, Wan G, Xia M, Chen D, Zhang Y, Wang Y, Guo F, Tan J, Liang H, Du B,Yu L(^*), Tan W, Duan X, Yuan Q(^*). Integrated Urinalysis Devices Based on Interface-Engineered Field Effect Transistor Biosensors Incorporated with Electronic Circuits. Advanced Materials. 2022;e2203224.（IF32.086）
4.Yu L(#), Zhou L(#),Cao G(#),Sunny Po，Huang B，Zhou X，Wang M, Yuan S, Wang Z, Wang S, Jiang H(^*),Optogenetic Modulation of Cardiac Sympathetic Never Activity to Protect Against Ventricular Arrhythmias. JACC. 2017;70（22）:2778-90（IF27.203）

5.Chen N, Du N, Shen R, He T, Xi J, Tan J, Bian G, Yang Y, Liu T, Tan W, Yu L(^*), Yuan Q(^*). Redox signaling-driven modulation of microbial biosynthesis and biocatalysis. Nat Commun. 2023 Oct 26;14(1):6800.（IF 16.66）
6.Hu B(#), Liu R(#), Tang X(#), Pan Y(#), Wang M(#), Tong Y(#), Ye G(#), Shen G(#), Ying R(#), Fu A, Li D, Zhao W, Peng J, Guo J, Men D, Yao M, Wang Y, Zhang H, Feng Z, Yu J, Chen J, Deng Z, Lu X, Zhang Y(^*), Li Y(^*), Liu B(^*),Yu L(^*), Li Y(^*), Lu J(^*), Liu T(^*). The concordance between the evolutionary trend and the clinical manifestation of the two SARS-CoV-2 variants. National Science Review. 2021; nwab073.（IF23.178）
7. Ye T(#), Lai Y(#), Wang Z(#), Zhang X, Meng G, Zhou L, Zhang Y, Zhou, Z, Deng J, Wang M, Wang Y, Zhang Q, Zhou X,Yu L(^*), Jiang H(^*), Xiao X(^*), Precise Modulation of Gold Nanorods for Protecting against Malignant Ventricular Arrhythmias via Near‐Infrared Neuromodulation. Adv. Funct. Mater. 2019;29,1902128.（IF19.924）
8.Zhang Y(#), Zhou L(#), Gao X, Liu C, Chen H, Zheng H, Gui J, Sun C,Yu L(^*), Guo S(^*). Performance-enhanced flexible piezoelectric nanogenerator via layer-by-layer assembly for self-powered vagal neuromodulation. Nano Energy. 2021;106319.（IF19.069）
9.Zhang Y(#), Zhou L(#), Liu C, Gao X, Zhou Z, Duan S, Deng Q, Song L, Jiang H(^*),Yu L(^*), Guo S(^*), Zheng H(^*). Performance-enhanced flexible piezoelectric nanogenerator via layer-by-layer assembly for self-powered vagal neuromodulation. Nano Energy. 2022;107420.（IF19.069）
10.Zhou L(#), Zhang Y(#), Cao G, Zhang C, Zheng C, Meng G, Lai Y, Zhou Z, Liu Z, Liu Z, Guo F, Dong X, Liang Z, Wang Y, Guo S, Zhou X(^*), Jiang H(^*), Yu L(^*). Wireless Self-Powered Optogenetic System for Long-Term Cardiac Neuromodulation to Improve Post-MI Cardiac Remodeling and Malignant Arrhythmia. Adv Sci (Weinh). 2023;10(9):e2205551.（IF17.521）

11 .Zhou Z(#), Liu C(#), Xu S(#), Wang J, Guo F, Duan S, Deng, Q, Sun J, Yu F, Zhou Y, Wang M, Wang Y, Zhou L, Jiang H(^*),Yu L(^*). Metabolism regulator adiponectin prevents cardiac remodeling and ventricular arrhythmias via sympathetic modulation in a myocardial infarction model. Basic Res Cardiol. 2022;117(1):34.（IF17.165）
12. Lai Y(#), Zhou X(#), Guo F(#), Jin X, Meng G, Zhou L, Chen H, Liu Z,Yu L(^*),Jiang H(^*). Non-invasive transcutaneous vagal nerve stimulation improves myocardial performance in doxorubicin-induced cardiotoxicity. Cardiovasc Res. 2021;cvab209.（IF13.081）
13.Yu L (#),Huang B(#), Po SS, Tan T, Wang M, Zhou L, Meng G, Yuan S, Zhou X, Li X, Wang Z1, Wang S, Jiang H (^*). Low-Level Tragus Stimulation for the Treatment of Ischemia and Reperfusion Injury in Patients With ST-Segment Elevation Myocardial Infarction. JACC Cardiovasc Interv. 2017;10(15):1511-1520.（IF11.3）
14. Meng G(#), Zhou X(#), Wang M, Zhou L, Wang Z, Wang M, Deng J, Wang Y, Zhou Z, Zhang Y, Lai Y, Zhang Q, Yang X,Yu L(^*), Jiang H(^*). Gut microbe-derived metabolite trimethylamine N-oxide activates the cardiac autonomic nervous system and facilitates ischemia-induced ventricular arrhythmia via two different pathways. EBioMedicine. 2019;44:656-664.（IF11.205）
15. Wang Z(#),Yu L(#), Wang S, Huang B, Liao K, Saren G, Tan T, Jiang H(^*). Chronic intermittent low-level transcutaneous electrical stimulation of auricular branch of vagus nerve improves left ventricular remodeling in conscious dogs with healed myocardial infarction. Circ Heart Fail. 2014;7(6):1014-21.（IF10.447）