Biography

Professor Gaohua Wang is currently the President of Renmin Hospital of Wuhan University and Director of the Institute of Neuropsychiatry of Hubei Province. Professor Wang’s endeavor in the area has won himself several scientific awards, of which one was the First Grade Award of Science and Technology Progress of Hubei Province, two were the Second Grade Award of Science and Technology Progress of Hubei Province and one was the First Grade Winner of Su Zonghua Mental Health Award.

Professor Wang has presided over and completed several research projects supported by the Stanley Medical Research Institute and the National Natural Science Foundation. He presided over one Key Project in the National Science and Technology Pillar Program and one Key Projects of Hubei Province. Currently several other major national scientific research projects are being progressed by Professor Wang and his team. In the academia, Professor Wang is a highly acclaimed author with more than 200 peer-reviewed articles published in scientific journals, of which 100 indexed by SCI. Professor Wang is currently the Deputy Chief Editor of Chinese Journal of Psychiatry and Editorial Committee member of Chinese Journal of Behavioral Medicine and Brain Science.

He has also authored or coauthored several national-approved psychiatry textbooks and monographs. Outside the professional realm, he is an active contributor to many Chinese authoritative newspapers and magazines with more than 100 articles devoted to psychology-related topics as well as others. He has educated 50 Masters and 20 Doctors. At present, there are14 Doctors and 9 Masters in his team.

Research

Professor Wang Gaohua has been committed to the basic and clinical research of depression for a long time. In the basic research direction, a variety of animal models of depression were established and improved, and molecular biology techniques were used to explore the possible pathogenesis of animal models of depression. In clinical research, the effects of new antipsychotic drugs on insulin level and the adverse reactions of drugs were explored. The above research results can provide a certain basis and ideas for the development and improvement of depression treatment drugs, and have important theoretical value and guiding significance for improving the treatment and prevention of depression and increasing the cure rate of depression.

Representative  Publications

1.Li D, Liu R, Wang M, Peng R, Fu S, Fu A, Le J, Yao Q, Yuan T, Chi H, Mu X, Sun T, Liu H, Yan P, Wang S, Cheng S, Deng Z, Liu Z, Wang G, Li Y, Liu T. 3β-Hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males. Cell Host Microbe. 2022, 30(3):329-339.e5.

2. Liang L, Chen J, Xiao L, Wang Q, Wang G. Mitochondrial modulators in the treatment of bipolar depression: a systematic review and meta-analysis. Transl Psychiatry. 2022, 10;12(1):4.

3. Hao K, Wang H, Zhang Y, Xie X, Huang H, Chen C, Xu S, Xu R, Shu C, Liu Z, Zhou Y, Reynolds GP, Wang G. Nicotinamide reverses deficits in puberty-born neurons and cognitive function after maternal separation. J Neuroinflammation. 2022, 19(1):232.

4. Zheng Y, Xiao L, Wang H, Chen Z, Wang G. A retrospective research on non-suicidal self-injurious behaviors among young patients diagnosed with mood disorders. Front Psychiatry. 2022,13:895892.

5. Han J, Shen M, Wan Q, Lv Z, Xiao L, Wang G. Risk factors for community-acquired pneumonia among inpatients with mental disorders in a tertiary general hospital. Front Psychiatry. 2022, 13:941198.

6. Liang L, Wang H, Hu Y, Bian H, Xiao L, Wang G. Oridonin relieves depressive-like behaviors by inhibiting neuroinflammation and autophagy impairment in rats subjected to chronic unpredictable mild stress. Phytother Res. 2022, 36(8):3335-3351.

7. Liang L, Yu J, Xiao L, Wang G. Sustained low-dose prophylactic early erythropoietin for improvement of neurological outcomes in preterm infants:A systematic review and meta-analysis. J Affect Disord. 2021, 282:1187-1192.

8. Wu Z, Zhou L, Sun L, Xie Y, Xiao L, Wang H, Wang G. Brief postpartum separation from offspring promotes resilience to lipopolysaccharide challenge-induced anxiety and depressive-like behaviors and inhibits neuroinflammation in C57BL/6J dams. Brain Behav Immun. 2021, 95:190-202.

9. Bian H, Xiao L, Liang L, Xie Y, Wang H, Wang G. RGFP966 is protective against lipopolysaccharide-induced depressive-like behaviors in mice by inhibiting neuroinflammation and microglial activation. Int Immunopharmacol. 2021, 101(Pt B):108259.

10. Wei Y, Wang G, Chen J, Xiao L, Wu Z, He J, Zhang N. Maternal deprivation induces cytoskeletal alterations and depressive-like behavior in adult male rats by regulating the AKT/GSK3β/CRMP2 signaling pathway. Physiol Behav. 2021, 242:113625.

11. Xiang D, Sun S, Wang G, Liu Z. Effects of CRMP2 DNA Methylation in the Hippocampus on Depressive-Like Behaviors and Cytoskeletal Proteins in Rats. Front Cell Neurosci. 2021, 15:644663.

12. Xie Y, Xiao L, Chen L, Zheng Y, Zhang C, Wang G. Integrated Analysis of Methylomic and Transcriptomic Data to Identify Potential Diagnostic Biomarkers for Major Depressive Disorder. Genes (Basel). 2021,12(2):178.

13. Liang L, Zheng Y, Xie Y, Xiao L, Wang G. Oridonin ameliorates insulin resistance partially through inhibition of inflammatory response in rats subjected to chronic unpredictable mild stress. Int Immunopharmacol. 2021, 91:107298.

14. Bian H, Wang G, Huang J, Liang L, Zheng Y, Wei Y, Wang H, Xiao L, Wang H. Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat. J Neuroinflammation. 2020, 17(1):166.

15. Kang L, Li Y, Hu S, Chen M, Yang C, Yang BX, Wang Y, Hu J, Lai J, Ma X, Chen J, Guan L, Wang G, Ma H, Liu Z. The mental health of medical workers in Wuhan, China dealing with the 2019 novel coronavirus. Lancet Psychiatry. 2020, 7(3):e14.