Biography

2005.9 – 2013.6, Wuhan University, School of Stomatology,   BS and DMD (8-year)

2013.7 – Present, Wuhan University, School and Hospital of Stomatology, Dentist in Department of Periodontology

2014.2 – 2017.9, University of Iowa, Postdoc research associate (mentor: Robert Cornell, Jeffery Murray)

2022.7 – Present, Wuhan University, TaiKang Center for Life and Medical Sciences, PI

Research

I have a combinatory background of both clinical dentistry and craniofacial developmental biology also a combinatory research interest in both craniofacial mesenchyme and dental epithelium. My research focuses on "regulation of craniofacial epithelial and mesenchymal lineage fate by genomic non-coding regions" to address the difficulties of precise diagnosis and treatment of craniofacial genetic defects: 1) systemic functional annotation of non-coding DNA and RNA related to craniofacial development, and in-depth excavation of the developmental phase of cranial neural crest mesenchymal and epithelial cells 2) to establish a functional research methodology for genetic mutations in cleft lip and palate, and to clarify the pathogenesis and diagnostic value of non-coding DNA mutations; 3) to develop specific non-coding RNA alternative therapeutic targets for craniosynostosis syndromes and periodontal bone loss.

Representative  Publications

1. Zhang H., Jiang C., Ji Y., Zhang Y., Chen Z., Cao Z.^*, Liu H.^* (2023) Osteoprotective Role of the Mir338 Cluster Ablation during Periodontitis. J Dent Res, 102(12): 1337-1347

2. Jin R., Zhang H., Lin C., Guo J., Zou W., Chen Z.^*, Liu H.^* (2023) Inhibition of Mir338 rescues the cleidocranial dysplasia in Runx2 mutant mice partially by the Hif1a-Vegfa axis. EXP MOL MED, 55(1):1-12

3. Xiao Y, Jiao S, He M, Lin D, Sun Y, Cao G, Chen Z^* , Liu H^*. (2022). Chromatin conformation of human oral epithelium can identify orofacial cleft missing functional variants. Int J Oral Sci 2022;14:43

4. Liu, H.^*, Duncan, K., Helverson, A., Kumari, P., Mumm, C., Xiao, Y., Carlson, J.C., Darbellay, F., Visel, A., Leslie, E., Breheny, P., Erives, A.J., & Cornell, R.A.^* (2020). Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18. eLife 9, e51325.

5. Liu, H., Leslie, E.J., Carlson, J.C., Beaty, T.H., Marazita, M.L., Lidral, A.C., and Cornell, R.A. (2017). Identification of common non-coding variants at 1p22 that are functional for non-syndromic orofacial clefting. Nature Communications 8, 14759.