Biography

Professor, Wuhan University

2021-present

Postdoc, University of California, Berkeley

Advisor: Prof. Ke Xu

2016-2021

Ph.D. in Chemistry, Arizona State University

Advisor: Prof. Nongjian (NJ) Tao

2010-2016

B.S. in Chemistry, Peking University

Advisor: Prof. Jian Pei

2006-2010

Research

The Xiang Lab’s research focuses on the developments of multi-dimensional and functional super-resolution imaging techniques to resolve nanoscale heterogeneity for lives and nanomaterials. To achieve this goal, our lab mainly works on the following directions:

I. Developments of novel multi-dimensional super-resolution imaging technique to resolve functional information, including diffusivity, polarity, electrical potential, enzyme activity, ion concentration and so on.

II. Visualizations of nanoscale heterogeneity for intracellular environments and nanomaterials to investigate the structure-function relationship at the single-molecule level.

III. Integration of multi-dimensional super-resolution imaging technique and electrochemical systems to unveil the interplay between electric and optical properties of single molecules, and explore how this interplay can affect biochemical activities at the nanoscale.

Representative  Publications

1. L. Xiang†, K. Chen†, R. Yan, W. Li & K. Xu^*, “Single-molecule displacement mapping unveils nanoscale heterogeneities in intracellular diffusivity”. Nat. Methods 2020, 17, 524-530

2. L. Xiang, M. Wojcik, S. J. Kenny, R. Yan, S. Moon, W. Li & K. Xu^*, “Optical characterization of surface adlayers and their compositional demixing at the nanoscale”. Nat. Commun. 2018, 9, 1435

3. L. Xiang^*, R. Yan, K. Chen, W. Li, K. Xu^*, "Single-molecule displacement mapping unveils sign-asymmetric protein charge effects on intraorganellar diffusion," Nano Lett. 2023, 23, 1711

4. L. Xiang†, K. Chen†, K. Xu^*, “Single molecules are your quanta: A bottom-up approach toward multidimensional super-resolution microscopy”. ACS Nano 2021, 15, 12483-12496

5. R. Sha†, L. Xiang†, C. Liu†, A. Balaeff, Y. Zhang, P. Zhang, Y. Li, D. N. Beratan^*, N. Tao^* & N. C. Seeman^*, “Charge splitters and charge transport junctions based on guanine quadruplexes”. Nat. Nanotech. 2018, 13, 316-321

6. L. Xiang, J. L. Palma, Y. Li, V. Mujica, M. A. Ratner & N. Tao*, “Gate-controlled conductance switching in DNA”, Nat. Commun. 2017, 8, 14471

7. C. Liu†, L. Xiang†, Y. Zhang, P. Zhang, Y. Li, N. Tao & D. N. Beratan*, “Engineering nanometer-scale coherence in soft matter”, Nat. Chem. 2016, 8, 941-945

8. L. Xiang, J. L. Palma, C. Bruot, V. Mujica, M. A. Ratner & N. Tao^*, “Intermediate tunnelling–hopping regime in DNA charge transport”, Nat. Chem. 2015, 7, 221-226