Biography

EDUCATION

2009.09-2012.06: M.D., Ph.D., School of Stomatology, Wuhan University, P.R. China.

2004.09-2009.06: B.A., School of Stomatology, Wuhan University, P.R. China.

PROFESSIONAL EXPERIENCE

2019.11-Present: Chief Physician, Professor, School and Hospital of Stomatology, Wuhan University, P.R. China.

2015.12-2019.10: Associate Chief Physician, Associate Professor, School and Hospital of Stomatology, Wuhan University, P.R. China.

2014.12-2017.12: Post-doctoral, School of Arts and Sciences, University of Pennsylvania, USA.

2013.06-2014.12: Post-doctoral, College of Chemistry and Molecular Sciences, Wuhan University, P.R. China.

2012.10-2015.11: Attending Physician, School and Hospital of Stomatology, Wuhan University, P.R. China.

Research

1. Rapid isolation and detection of extracellular vesicles.

2. Biogenesis mechanism and biological function of extracellular vesicles.

3. Clinical transformation of extracellular vesicles.

Representative  Publications

1. Liu JY^#, Yu ZL^#, Fu QY, Zhang LZ, Li JB, Wu M, Liu B, Chen G^*. Immunosuppressive effect of small extracellular vesicle PD-L1 is restricted by co-expression of CD80. Brit J Cancer. 2023;129(6):925-934.

2. Zhang LZ^#, Yang JG^#, Xia HF, Huang J, Liu HM, Wu M, Liu B, Wang WM^*, Chen G^*. PD-1 Carried on small extracellular vesicles leads to OSCC metastasis. J Dent Res. 2023;102(7):795-805.

3. Li Y^#, Chen YH^#, Liu BY, Nie Q, Li LJ, Duan X, Wu LZ, Chen G*. Deciphering the heterogeneity landscape of mesenchymal stem/stromal cell-derived extracellular vesicles for precise selection in translational medicine. Adv Healthc Mater. 2023;12(15):e2202453.

4. Xia HF^#, Yu ZL^#, Zhang LJ, Lin SL, Zhao Y, Huang J, Fu DD, Xie QH, Liu HM, Zhang ZL, Zhao YF, Wu M, Zhang W^*, Pang DW^*, Chen G^*. Real-time dissection of the transportation and miRNA-release dynamics of small extracellular vesicles. Adv Sci. 2023;10(7):e2205566.

5. Xiao BL^#, Wang XL^#, Xia HF, Zhang LZ, Wang KM, Chen ZK, Zhong YH, Jiang HG, Zhou FX, Wang W, Chen GL, Chen G^*. HRS regulates small extracellular vesicle PD-L1 secretion and is associated with anti-PD-1 treatment efficacy. Cancer Immunol Res. 2023;11(2):228-240.

6. Xu R^#, Yu ZL^#, Liu XC, Xie QH, Wu M^*, and Chen G^*. Aptamer-assisted traceless isolation of PD-L1-positive small extracellular vesicles for dissecting their subpopulation signature and function. Anal Chem. 2023;95(2):1016-1026.

7. Yu ZL^#, Liu XC^#, Wu M, Shi S, Fu QY, Jia J^*, Chen G^*. Untouched isolation enables targeted functional analysis of tumour-cell-derived extracellular vesicles from tumour tissues. J Extracell Vesicles. 2022;11(4):e12214.

8. Yu ZL^#, Zhao Y^#, Miao F, Wu M, Xia HF, Chen ZK, Liu HM, Zhao YF, Chen G^*. In situ membrane biotinylation enables the direct labeling and accurate kinetic analysis of small extracellular vesicles in circulation. Anal Chem. 2021;93(31):10862-10870.

9. Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu ZL, Yang JG, Wang BK, Sun HH, Xia HF, Man QW, Zhong WQ, Antelo LF, Wu B, Xiong XP, Liu XM, Guan L, Li T, Liu SJ, Yang RF, Lu YT, Dong LY, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu YL, Kim JY, Chen YH, Dong HD, Zhao YF, Karakousis GC, Gangadhar TC, Schuchter LM, Herlyn M, Wherry EJ, Xu XW^*, Guo W^*. Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response. Nature. 2018;560(7718):382-386.

10. Yu ZL, Zhang W, Zhao JY, Zhong WQ, Ren JG, Wu M, Zhang ZL, Pang DW, Zhao YF, Chen G^*. Development of a dual-modally traceable nanoplatform for cancer theranostics using natural circulating cell-derived microparticles in oral cancer patients. Adv Funct Mater. 2017; 27(40):1703482.

11. Zhang W^#, Yu ZL^#, Wu M, Ren JG, Xia HF, Sa GL, Zhu JY, Pang DW, Zhao YF^*, Chen G^*. Magnetic and folate functionalization enables rapid isolation and enhanced tumor-targeting of cell-derived microvesicles. ACS Nano. 2017;11(1):277-290.

12. Chen G, Zhu JY, Zhang ZL, Zhang W, Ren JG, Wu M, Hong ZY, Lv C, Pang DW^*, Zhao YF^*. Transformation of cell-derived microparticles into quantum-dot-labeled nanovectors for antitumor siRNA delivery. Angew Chem Int Ed. 2015;54(3):1036-1040.