Biography
Professional EEducation
2003 B.S, Nanjing University
2010 PhD, University of Colorado Anschutz Medical Campus
xperience and Academic Appointments
2010-2016 Postdoctoral Associate Massachusetts Institute of Technology
Mentor: Robert Langer, Daniel Anderson
2016-2018 Research Scientist Vertex Pharmaceuticals
2018- Wuhan University
Research
Research Areas:
1.New genome editing tools
2.Next generation delivery systems for therapeutic genome editing
Representative Publications
1. Jing Wu, Pan Gao, Ya-jing Shi, Caixiang Zhang, Xiaohan Tong, Huidi Fan, Xi Zhou, Ying Zhang, Hao Yin, Characterization of a thermostable Cas12a ortholog. Cell Insight, Available online 11 October 2023, 100126
https://www.sciencedirect.com/science/article/pii/S2772892723000500
2. Xiaohan Tong#, Kun Zhang#, Yang Han#, Tianle Li, Min Duan, Ruijin Ji, Xianguang Wang, Xi Zhou, Ying Zhang, Hao Yin, Accepted in Nature Chemical Biology, 2023
3. An J#, Zhang C#, Qiu H#, Zhang H#, Chen Q, Zhang Y, Lei X, Zhang C, Yin H *, Zhang Y*. Enhanced human T cell reprogramming by mitigating cGAS-STING activation via isotonic buffer mediated non-viral delivery. Nature Biomedical Engineering, 2023
https://www.nature.com/articles/s41551-023-01073-7
4. Lu S#, Tong X#, Han Y#, Zhang K, Zhang Y, Chen Q, Duan J, Lei X, Huang M, Qiu Y, Zhang DY, Zhou X, Zhang Y*, Yin H*, Fast and sensitive detection of SARS-CoV-2 RNA using suboptimal protospacer adjacent motifs for Cas12a, Nature Biomedical Engineering, 2022 Mar;6(3):286-297
*Journal highlight: “Rethinking diagnostics for pandemic readiness” Nature Biomedical Engineering
https://www.nature.com/articles/s41551-022-00861-x
5. Wang J#, He Z#, Wang G#, Zhang R#, Duan J, Gao P, Lei X, Qiu H, Zhang C, Zhang Y, Yin H*, Efficient targeted insertion of large DNA fragments without DNA donor, Nature Methods, 2022 Mar;19(3):331-340.
https://www.nature.com/articles/s41592-022-01399-1
6. Wang L#, Xue W#, Zhang H#, Gao R#, Qiu H#, Wei J, Zhou L, Lei YN, Wu X, Li X, Liu C, Wu J, Chen Q, Ma H, Huang X, Cai C, Zhang Y, Yang B*, Yin H*, Yang L*, Chen J*, Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations. Nature Cell Biology. 2021 May;23(5):552-563.
https://www.nature.com/articles/s41556-021-00671-4
7. Song CQ#, Jiang T#, Richter M, Rhym LH, Koblan LW, Zafra MP, Schatoff EM, Doman JL, Cao Y, Dow LE, Zhu LJ, Anderson DG, Liu DR*, Yin H*, Xue W*, Adenine base editing in an adult mouse model of tyrosinaemia. Nature Biomedical Engineering. 2020 Jan;4(1):125-130.
*Journal highlight: “Correcting tyrosinaemia via a point mutation” and “Towards better base editing” Nature Biomedical Engineering
*F1000 Recommendation
https://www.nature.com/articles/s41551-019-0357-8
8. Lu S#, Li F#, Chen Q, Wu J, Duan J, Lei X, Zhang Y, Zhao D, Bu Z*, Yin H*, Rapid detection of African swine fever virus using Cas12a-based portable paper diagnostics Cell Discovery 2020 volume 6:18
https://www.nature.com/articles/s41421-020-0151-5/
9. Yin H*, Xue W*, Anderson DG* CRISPR-Cas: a tool for cancer research and therapeutics. Nature Reviews Clinical Oncology. 2019 May;16(5):281-295.
Selected in “Collections of CRISPR publications” by Nature to celebrate 2020 Nobel Prize in Chemistry
https://www.nature.com/articles/s41571-019-0166-8
10. Chen Q, Zhang Y*, Yin H*, Recent advances in chemical modifications of guide RNA, mRNA and donor template for CRISPR-mediated genome editing. Advanced Drug Delivery Reviews 2021 Jan;168:246-258
https://pubmed.ncbi.nlm.nih.gov/33122087/
11. Wu J, Yin H*. Engineering guide RNA to reduce the off-target effects of CRISPR. Journal of Genetics and Genomics. 2019 Nov 20;46(11):523-529.
https://www.sciencedirect.com/science/article/pii/S1673852719301766
12. Zhang HX, Zhang Y*, Yin H*. Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9. Molecular Therapy. 2019 Apr 10;27(4):735-746
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(19)30017-6
13. Yin H#, Song CQ#, Suresh S, Kwan SY, Wu Q, Walsh S, Ding J, Bogorad RL, Zhu LJ,Wolfe SA, Koteliansky V, Xue W, Langer R, Anderson DG，Partial DNA-guided Cas9 enables genome editing with reduced off-target activity. Nature Chemical Biology.2018, 14(3):311-316.
*Journal highlight: Nature Catalysis “Better guidance is cheaper”
BioCentury | Altering Cas9 and its guide for fewer off-target edits.
*Selected in “Collections of CRISPR publications” by Nature to celebrate 2020 Nobel Prize in Chemistry
https://www.nature.com/articles/nchembio.2559/
14. Yin H, Song CQ, Suresh S, Wu Q, Walsh S, Rhym LH, Mintzer E, Bolukbasi MF, Zhu LJ, Kauffman K, Mou H, Oberholzer A, Ding J, Kwan SY, Bogorad RL, Zatsepin T, Koteliansky V, Wolfe SA, Xue W, Langer R, Anderson DG. Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing. Nature Biotechnology 2017, 35(12):1179-1187.
*Featured by VOICE of America / US Researchers Use Nanotech, Gene Editing to Edit Cholesterol Gene VICE / CRISPR Can Now Edit Genes Using Nanoparticles Instead of Viruses Yahoo News / CNBC / Nanotech, gene editing used to edit cholesterol gene-US study
Genetic Engineering & Biotechnology News / CRISPR/Cas9 Delivery Goes Nano with Enhanced Guide RNA Fiercebiotech / MIT scientists propose a safer way to edit genes with CRISPR / MIT News / Science Daily / Bioscience Technology / Medical News Today/Business Insider UK / The Medical News / Phys.org.
*F1000 Recommendation
https://www.nature.com/articles/nbt.4005
15. Yin H, Kauffman KJ and Anderson DG. Delivery technologies for genome editing. Nature Reviews Drug Discovery 2017, 16(6): 387-399.
https://www.nature.com/articles/nrd.2016.280
16. Yin H, Song CQ, Dorkin JR, Zhu L, Li Y, Wu Q, Park A, Yang J, Suresh S, Bizhanova A, Gupta A, Bolukbasi M, Walsh S, Bogorad R, Gao G, Weng Z, Dong Y, Koteliansky V, Wolfe S, Langer R, Xue W and Anderson DG. Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo. Nature Biotechnology 2016,34(3):328-33.
*Featured by MIT News / Science Daily / Bioscience Technology / Medical News Today / Deutsches Ärzteblatt / Nanowerk / Nanotechnology Now /The Medical News / Phys.org
https://www.nature.com/articles/nbt.3471
17. Yin H#, Bogorad RL#, Barnes C, Walsh S, Zhuang I, Nonaka H, Ruda V, Kuchimanchi S, Nechev L, Akinc A, Xue W, Zerial M, Langer R, Anderson DG, Koteliansky V. RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver. Journal of Hepatology 2016, 64(4):899-907.
https://www.sciencedirect.com/science/article/pii/S0168827815007862
18. Mou H, Kennedy Z, Anderson DG, Yin H*, and Xue W*, Precision cancer mouse models through genome editing with CRISPR-Cas9. Genome Medicine 2015, 7(1):53.
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-015-0178-7
19. Yin H#, Xue W#, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T, Anderson DG (2014) Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nature Biotechnology 2014, 32(6):551-3.
*100 top stories of 2014 by Discover Magazine as “A Giant Step for Gene Surgery”
*Top Ten Genetics Stories for 2014: Incredible Achievements, by the DNA Exchange
*Journal highlight: Nature Medicine (CRISPR technology for gene therapy) | A cover story in Science–Business eXchange of Nature Publishing Group | BioTechniques
*Featured by MIT News /The Independent: Front Page Headlines/ Fox News / The Times of India / Science Daily / Medical daily / The Voice of Russia / Phys.org /
*F1000 Recommendation.
*Selected in “Collections of CRISPR publications” by Nature to celebrate 2020 Nobel Prize in Chemistry
https://www.nature.com/articles/nbt.2884
20. Xue W#, Chen S#, Yin H#, Tammela T, Joshi N, Papagiannakopoulos T, Cai W, Yang G, Bronson R, Crowley D, Zhang F, Anderson DG, Sharp PA, Jacks T. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature 2014, 514(7522):380-4.
*Journal highlight: Hepatology (Cutting short the path to murine liver cancer models)
*Featured by MIT News / Science Daily / Medical Press / Newswise / F1000Prime Recommendation.
https://www.nature.com/articles/nature13589
21. Yin H, Kanasty RL, Eltoukhy AA, Vegas AJ, Dorkin JR, Anderson DG. Non-viral vectors for gene-based therapy. Nature Reviews Genetics 2014, 15(8):541-55.
https://www.nature.com/articles/nrg3763
22. Bogorad RL#, Yin H#, Zeigerer A, Nonaka H, Ruda VM, Zerial M, Anderson DG, Koteliansky V Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice. Nature Communications 2014, 5:3869.
*Journal highlight: Nature Reviews Gastroenterology & Hepatology (Loss of integrin β1 impairs liver regeneration and HCC progression)
https://www.nature.com/articles/ncomms4869
23. Yin H, Cheng L, Holt M, Hail N, Jr., Maclaren R, Ju C, “Lactoferrin protects against acetaminophen-induced liver injury in mice”, Hepatology 2010, doi: 10.1002/hep.23476.
https://pubmed.ncbi.nlm.nih.gov/20099297/
24. Yin H, Cheng L, Langenbach R, Ju C, “Prostaglandin I(2) and E(2) mediate the protective effects of cyclooxygenase-2 in a mouse model of immune-mediated liver injury”, Hepatology 2007, doi: 10.1002/hep.21493.
https://pubmed.ncbi.nlm.nih.gov/17187424
Book Chapter
"Genome Editing for Genetic Lung Diseases" Pharmaceutical Inhalation Aerosol Technology, Third Edition
Chimeric DNA-RNA Guide RNA Designs. Methods Mol Biol. 2021;2162:79-85
