Biography

EDUCATION

2003-2008: Ph.D. Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. (Mentor: Dr. Tao Xu)

1999-2003: B.S (Biophysics), College of Physics, Nankai University, Tianjin China.

RESEARCH EXPERIENCE:

2015.3-Present: Principal Investigator, Professor, College of Life Science,   Taikang Center for Life and Medical Sciences, Wuhan University, China.  

2008.8-2015.2: Postdoctoral fellow. Howard Hughes Medical Institute &  UTsouthwestern medical center (Supervisor: Dr. Helen Hobbs and Dr. Jonathan Cohen).  

Research

Dyslipidemia is a leading risk factor for cardiovascular diseases, with high prevalence both in China and worldwide. Over nutrition and a sedentary life style contribute to the dyslipidemia. However, different populations have varying susceptibility to these environmental factors, underscoring the importance of genetics. Population studies suggest that over 50% of dyslipidemia cases are caused by genetics risk factors. Our research aims to elucidate the genetic risk factors underling dyslipidemia. By employing animal models, cell biology, biochemistry, and cutting-edge technologies such as gene editing, we attempt to uncover the pathological functions of key human mutations in dyslipidemia, aiming to lay the ground for novel drug discovery.

Representative  Publications

1. Liu XM^#, Zhang YL^#, Han BQ, Li L, Li Y, Ma YF, Kang SJ, Li Q, Kong LK, Huang K, Song BL, Liu Y, Wang Y. Postprandial exercise regulates tissue-specific triglyceride uptake through Angiopoietin-like proteins. JCI insight, 2024 Aug 22;9(16).

2. Hu X, Chen F, Jia L, Long A, Peng Y, Li X, Huang J, Wei X, Fang X, Gao Z, Zhang M, Liu X, Chen YG, Wang Y, Zhang H, Wang Y. A gut-derived hormone regulates cholesterol metabolism. Cell. 2024 Mar 28;187(7):1685-1700.e18. doi: 10.1016/j.cell.2024.02.024. Epub 2024 Mar 18.

3. Wilkins BP, Finch AM, Wang Y, Smith NJ. Orphan GPR146: an alternative therapeutic pathway to achieve cholesterol homeostasis?. Trends Endocrinol Metab. 2022 Jul;33 (7):481-492. doi: 10.1016/j.tem.2022.04.008. Epub 2022 May 10.

4. Wang JK, Li Y, Zhao XL, Liu YB, Tan J, Xing YY, Adi D, Wang YT, Fu ZY, Ma YT, Liu SM, Liu Y, Wang Y, Shi XJ, Lu XY, Song BL, Luo J. Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and Protects Against Atherosclerosis. Circulation. 2022 Mar;145 (9):675-687.

5. Han FF^#, Liu X^#, Chen CF^#, Liu YN^#, Du MK, Zhou Y, Liu Y, Song BL, He HH, Wang Y*. Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice. Cell Research. 2020 Apr;30(4):363-365

6. He BS^#, Kang SJ^#, Chen Z, Liu X, Wang JK, Li XD, Liu XM, Zheng L, Luo MC, Wang Y^*. Hypercholesterolemia risk associated Abca6 does not regulate lipoprotein metabolism in mice or hamster. BBA - Molecular and Cell Biology of Lipids. 2021 Jul 15; 159006. doi: 10.1016/j.bbalip.2021.159006

7. Wang X, Wang H, Xu B, Huang D, Nie C, Pu L, Zajac GJM, Yan H, Zhao J, Shi F, Emmer BT, Lu J, Wang R, Dong X, Dai J, Zhou W, Wang C, Gao G, Wang Y, Willer C, Lu X, Zhu Y, Chen XW. Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis. Cell Metab. 2021 Feb 2;33(2):350-366

8. Li XD, Zhang YL, Zhang MZ, Wang Y*. GALNT2 regulates ANGPTL3 cleavage in cells and in vivo of mice. Sci Rep. 2020 Sep 30;10 (1):16168. doi: 10.1038/s41598-020-73388-3

9. Fu T, Guan YY, Xu JJ, Wang Y*. APP, APLP2 and LRP1 interact with PCSK9 but are not required for PCSK9-mediated degradation of the LDLR in vivo. BBA - Molecular and Cell Biology of Lipids. 2017 Sep;1862(9):883-889

10. Adi D, Lu XY, Fu ZY, Wei J, Baituola G, Meng YJ, Zhou YX, Hu A, Wang JK, Lu XF, Wang Y, Song BL, Ma YT, Luo J. IDOL G51S Variant Is Associated With High Blood Cholesterol and Increases Low-Density Lipoprotein Receptor Degradation. Arterioscler Thromb Vasc Biol. 2019 Dec;39(12):2468-247

11. Chen L*, Chen XW*, Huang X*, Song BL*, Wang Y*, Wang Y*. Regulation of glucose and lipid metabolism in health and disease. Sci China Life Sci. 2019 Nov;62(11):1420-1458

12. Zhang YY, Fu ZY, Wei J, Qi W, Baituola G, Luo J, Meng YJ, Guo SY, Yin H, Jiang SY, Li YF, Miao HH, Liu Y, Wang Y, Li BL, Ma YT*, Song BL*. A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption. Science. 2018 Jun 8;360(6393):1087-1092

13. Wang Y, McNutt M, Banfi S, Levin M, Holland W, Gusarova V, Gromada J, Cohen JC*, Hobbs HH*. Hepatic ANGPTL3 Regulates Adipose Tissue Energy Homeostasis. Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11630-5.

14. Wang Y, Gusarova V, Banfi S, Gromada J, Valenzuela D, Cohen JC*, Hobbs HH*. Inactivation of ANGPTL3 Reduces Hepatic VLDL-triglyceride Secretion. J Lipid Res. 2015 Jul;56(7):1308-17.

15. Wang Y^#, Quagliarini F^#, Gusarova V, Gromada J, Valenzuela D, Cohen JC*, Hobbs HH*. Mice Lacking ANGPTL8 (Betatrophin) Manifest Disrupted Triglyceride Metabolism Without Impaired Glucose Homeostasis. Proc Natl Acad Sci U S A. 2013 Oct 1. 110(40):16109-14

16. Quagliarini F*, Wang Y*, Kozlitina J, Grishin N, Hyde R, Boerwinkle E, Cohen JC, Hobbs HH . Atypical angiopoietin-like protein that regulates ANGPTL3. Proc Natl Acad Sci U S A. 2012 Nov 27. 109(48):19751-6

17. Wang Y, Huang Y, Hobbs HH, Cohen JC. Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR. J Lipid Res. 2012 Sep;53(9):1932-43.

18. Chen Y*, Wang Y*, Zhang J*, Deng Y, Jiang L, Song E, Wu XS, Hammer JA, Xu T, Lippincott-Schwartz J. Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes. J Cell Biol. 2012 Aug 20;198(4):545-60

19. Bai L*, Wang Y*, Fan J*, Chen Y, Ji W, Qu A, Xu P, James DE & Xu T Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action. Cell Metab. 2007 Jan;5(1):47-57