Biography

2016-Now   Wuhan University, Professor

2010-2016   University of Pennsylvania, Postdoc

2005-2010   Wuhan University, Ph.D.

2001-2005   Wuhan University, B.S.

Research

My lab mainly focuses on the genetics mechanisms of human infertility and assisted reproductive technologies, including: 

(1) Genetics mechanisms of meiosis;

(2) Genetics mechanisms of gonad development;

(3) Assisted reproductive technology;

(4) Male contraceptive. We are dedicated to improving human reproductive health so that everyone can have a healthy child.

Representative  Publications

（1）Huijuan Lin # , Keren Cheng # , Hiroshi Kubota , Yemin Lan , Simone S Riedel , Kazue Kakiuchi , Kotaro Sasaki , Kathrin M Bernt , Marisa S Bartolomei , Mengcheng Luo*, P Jeremy Wang*，Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells，Genes&Development, 2022.

（2）Junfeng Zhan, Peng Cui, Ziqi Yu, Wei Qu , Mengcheng Luo﹡, SDX on the X chromosome is required for male sex determination, Cell Research, 2021.

（3）Yongjuan Guan, N. Adrian Leu, Jun Ma, Lukáš Chmátal, Gordon Ruthel, Jordana C. Bloom, Michael A. Lampson, John C. Schimenti, Mengcheng Luo* and P. Jeremy Wang*, 'Skp1 Drives the Prophase I to Metaphase I Transition During Male Meiosis', Science Advances, Vol. 6, no. 13, eaaz2129 (2020).

（4） M. Luo, J. Zhou, N. A. Leu, C. M. Abreu, J. Wang, M. C. Anguera, D. G. de Rooij, M. Jasin, and P. J. Wang, 'Polycomb Protein Scml2 Associates with Usp7 and Counteracts Histone H2a Ubiquitination in the XY Chromatin During Male Meiosis', PLoS Genet, 11 (2015), e1004954.

（5）M. Luo, F. Yang, N. A. Leu, J. Landaiche, M. A. Handel, R. Benavente, S. La Salle, and P. J. Wang, 'Meiob Exhibits Single-Stranded DNA-Binding and Exonuclease Activities and Is Essential for Meiotic Recombination', Nat Commun, 4 (2013), 2788.