Biography

M.D., Third Class Professor of Urology, First Class Chief Physician, M.S., Ph.D. Supervisor; Vice President of Wuhan University People's Hospital, concurrently Director of the Department of Urology, Discipline Leader of the Department of Urology, Director of Urology and Nephrology Hospital, Executive Director of the Institute of Medical-Industrial Cross-Fusion and Executive Director of the Institute of Medical Artificial Intelligence. Cheng Fan is a visiting scholar at the University of Oxford, UK and the University of Nancy, France. He is the head of Hubei Leading Medical Talent and Hubei Famous Doctor Studio and an expert of the 13th batch of 3551 Talent Program of Wuhan East Lake New Technology Development Zone. Cheng Fan has long been engaged in basic and clinical research on urinary stones and minimally invasive treatment techniques for benign and malignant prostate diseases.

Research

Basic research:

1. Molecular mechanism of kidney stone formation and pathogenesis of renal fibrosis after kidney stone injury;

2. Mechanisms of prostate cancer progression and drug resistance to endocrine therapy.

Medical-Industrial Cross-Fusion research:

1. Innovative research and development of PCNL surgical equipment based on CT-US fusion imaging and artificial intelligence and improvement of clinical technology system;

2. Research on prostate cancer puncture robot based on CT-MRI fusion images;

3. Clinical validation, promotion and equipment improvement of minimally invasive implantable prostatic urethral lift surgery system

(1) To validate the safety and efficacy of the Urowell surgical system for the treatment of benign prostatic hyperplasia (BPH) through a multicenter clinical study and establish the criteria for this surgical procedure;

(2) Research on new anchor materials based on carbide coating technology;

(3) Equipment improvement of minimally invasive implantable prostate lift (Urowell) surgical system.

Representative  Publications

1. Li B^#, Xia Y^#, Mei S^#, Ye Z, Song B, Yan X, Lin F, Rao T, Yu W, Mei C, Lv J, Wu M, Zhou X*, Cheng F*. Histone H3K27 methyltransferase EZH2 regulates apoptotic and inflammatory responses in sepsis-induced AKI. Theranostics. 2023;13(6):1860-1875.（IF:11.60,一区）

2. Hu W^#, Li M^#, Ning J ^#, Tang Y, Song T, Li L, Zou F, Cheng F*, Yu W*. FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression. J Exp Clin Cancer Res. 2023 Nov 2;42(1):290. (IF: 11.3,一区)

3. Ye Z^#, Xia Y^#, Li L^#, Li B, Chen L, Yu W, Ruan Y, Rao T, Zhou X*, Cheng F*. p53 deacetylation alleviates calcium oxalate deposition-induced renal fibrosis by inhibiting ferroptosis. Biomed Pharmacother. 2023;164:114925.（IF:7.42,一区）

4. Xing J^#, Chen W^#, Chen K, Zhu S, Lin F, Qi Y, Zhang Y, Han S, Rao T, Ruan Y, Zhao S, Yu W*, Chengw F*. TFAP2C Knockdown Sensitizes Bladder Cancer Cells to Cisplatin Treatment via Regulation of EGFR and NF-κB. Cancers (Basel). 2022;14(19):4809. （IF:6.58,一区）

5. Zhu S^#, Ma AH^#, Zhu Z^#, Adib E, Rao T, Li N, Ni K, Chittepu VCSR, Prabhala R, Garisto Risco J, Kwiatkowski D, Mouw K, Sonpavde G, Cheng F*, Pan C*. Synergistic antitumor activity of pan-PI3K inhibition and immune checkpoint blockade in bladder cancer. Journal for immunotherapy of cancer.2021;9(11).（IF:12.47,一区）

6. Zhao S^#, Li W^#, Yu W, Rao T, Li H, Ruan Y, Yuan R, Li C, Ning J, Li S, Chen W, Cheng F*, Zhou X*. Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys. Theranostics. 2021;11(18):8660-8673.（IF:11.60,一区）

7. Zhou X^#, Zhao S^#, Li W^#, Ruan Y, Yuan R, Ning J, Jiang K, Xie J, Yao X, Li H, Li C, Rao T*, Yu W*, Cheng F*. Tubular cell-derived exosomal miR-150-5p contributes to renal fibrosis following unilateral ischemia-reperfusion injury by activating fibroblast in vitro and in vivo. Int J Biol Sci. 2021;17(14):4021-4033.（IF:10.75,一区）

8. Ning J^#, He K^#, Yu W, Li H, Rao T, Ruan Y, Li W*, Cheng F*. Long Non-coding RNA MEG3 Promotes Pyroptosis in Testicular Ischemia-Reperfusion Injury by Targeting MiR-29a to Modulate PTEN Expression. Frontiers in cell and developmental biology. 2021;9:671613.（IF:6.08,一区）

9. Xia Y^#, Zhou X^#, Ye Z, Yu W, Ning J, Ruan Y, Yuan R, Lin F, Ye P, Zheng D, Rao T*, Cheng F*. Construction and Analysis of Immune Infiltration-Related ceRNA Network for Kidney Stones. Frontiers in genetics. 2021;12:774155.（IF:4.77,一区）

10. Han S^#, Lin F^#, Ruan Y, Zhao S, Yuan R, Ning J, Jiang K, Xie J, Li H, Li C, Rao T, Yu W, Xia Y, Zhou X*, Cheng F*. miR-132-3p promotes the cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells by targeting SIRT1 via the NF-κB pathway. International immunopharmacology. 2021;99:108022.（IF:5.70,一区）

11. Li P^#, Chen L^#, Liu Z^#, Pan J, Zhou D, Wang H, Gong H, Fu Z, Song Q, Min Q, Ruan S, Xu T, Cheng F*, Li X*. Clinical features and short-term outcomes of elderly patients with COVID-19. International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases. 2020;97:245-250.（IF:12.07,一区）

12. Zhang J^#, Zhu L^#, Yao L^#, Ding X, Chen D, Wu H, Lu Z, Zhou W, Zhang L, An P, Xu B, Tan W, Hu S, Cheng F*, Yu H*. Deep learning-based pancreas segmentation and station recognition system in EUS: development and validation of a useful training tool (with video). Gastrointest Endosc. 2020;92(4):874-885.（IF:10.30,一区）

13. Yang K^#, Xiao Y, Xu T, Yu W, Ruan Y, Luo P*, Cheng F*. Integrative analysis reveals CRHBP inhibits renal cell carcinoma progression by regulating inflammation and apoptosis. Cancer gene therapy. 2020;27(7-8):607-618.（IF:5.85,一区）

14. Li H^#, Li Q^#, Ma Z^#, Zhou Z, Fan J, Jin Y, Wu Y, Cheng F*, Liang P*. AID modulates carcinogenesis network via DNA demethylation in bladder urothelial cell carcinoma. Cell Death Dis.2019;10(4):251.（IF:9.69,一区）

15. Han S^#, Lin F^#, Qi Y^#, Liu C, Zhou L, Xia Y, Chen K, Xing J, Liu Z, Yu W, Zhang Y, Zhou X, Rao T*, Cheng F*. HO-1 Contributes to Luteolin-Triggered Ferroptosis in Clear Cell Renal Cell Carcinoma via Increasing the Labile Iron Pool and Promoting Lipid Peroxidation. Oxid Med Cell Longev. 2022;2022:3846217.（IF:6.54,二区）