Biography

Work Experience

11/2024 - Present Taikang Medical School (School of Basic Medical Sciences), Wuhan University (Professor)

11/2024 - Present TaiKang Center for Life and Medical Sciences, Wuhan University (PI)

03/2022-10/2024 Horae Gene Therapy Center, Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School (Instructor)

09/2018-03/2022 Horae Gene Therapy Center, Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School (Postdoctoral Fellow)

Education

09/2010 - 07/2018 The Institute of Genetics and Developmental Biology, Chinese Academy of Sciences (Ph.D.)

Research

Rare diseases have a low incidence but are highly diverse. As a populous country, China has a significant number of patients with rare diseases, creating an urgent demand for safe and effective therapeutic drugs. Approximately 80% of rare diseases are associated with genetic mutations and are classified as hereditary conditions. Our research group is primarily focused on gene therapy for rare genetic disorders: 1) developing rAAV-based gene therapies for rare diseases, and 2) exploring innovative therapeutic strategies and viral vectors.

Representative  Publications

1. Wang, J.#, Poskitt, L.#, Gallagher, J.#, et al., Gray-Edwards, H.*, Gao, G.*, Strauss, K.*, and Wang, D.* (2024). BCKDHA-BCKDHB digenic gene therapy in murine and bovine models of classic maple syrup urine disease. Science Translational Medicine. Minor revision.

Wang, J., Gao, G.*, and Wang, D.* (2024). Developing AAV-delivered nonsense suppressor tRNAs for neurological disorders. Neurotherapeutics. 21(4):e00391.

2. Liu, H., Zhang, Y., Yip, M., Ren, L., Liang, J., Chen, X., Liu, N., Du, A., Wang, J., Chang, H., Oh, H., Zhou, C., Xing, R., Xu, M., Guo, P., Gessler, D., Xie, J., Tai, P.W.L., Gao, G., Wang, D. (2024). Producing high-quantity and high-quality recombinant adeno-associated virus by low-cis triple transfection. Mol Ther Methods Clin Dev. 32(2):101230.

3. Wang, J.#, Zhang, Y.#, Mendonca, C.A.#, Yukselen, O., Muneeruddin, K., Ren, L., Liang, J., Zhou, C., Xie, J., Li, J., Jiang, Z., Kucukural, A., Shaffer, S.A., Gao, G.*, and Wang, D.* (2022). AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice. Nature. 604(7905):343-348.

4.Ibraheim, R., Tai, P.W.L., Mir, A., Javeed, N., Wang, J., Rodríguez, T.C., Namkung, S., Nelson, S., Khokhar, E.S., Mintzer, E., Maitland, S., Chen, Z., Cao, Y., Tsagkaraki, E., Wolfe, S.A., Wang, D., Pai, A.A., Xue, W., Gao, G., Sontheimer, E.J. (2021). Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo. Nat. Commun. 12(1):6267.                                                                

5.Wang, J., and Ding, M. (2018). Robo and Ror Function in a Common Receptor Complex to Regulate Wnt-mediated Neurite Outgrowth in Caenorhabditis elegans. PNAS. 115(10):E2254-E2263. (Recommended in F1000Prime)

6.Cheng, Y.#, Wang, J.#, Wang, Y., and Ding, M. (2015). Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle. eLife. 4:e05118.

7.Zhang, J., Li, X., Jevince, A.R., Guan, L., Wang, J., Hall, D.H., Huang, X., and Ding, M. (2013). Neuronal target identification requires AHA-1-mediated fine-tuning of Wnt signaling in C. elegans. PLoS Genet. 9(6):e1003618.