CN

Faculty

Home  >  Faculty  >  Content


E-mail：

zhengliuent@hotmail.com

Biography

Liu Zheng, a second level professor, chief   physician, and doctoral supervisor, Secretary of the Party Committee of   Zhongnan Hospital of Wuhan University, recipient of the National Outstanding   Youth Fund, recipient of the National Talent Project of the Ministry of   Education, recipient of the National Talent Project of the Ministry of   Science and Technology, Vice Chairman of the Allergy Branch of the Chinese   Medical Association, Vice Chairman of the Otolaryngology Head and Neck   Surgery Branch of the Chinese Medical Association, and Chairman of the   Allergy Branch of the Hubei Medical Association Fellow of American Academy of   Allergy, Asthma and Immunology。 serve   as Clinical and Experimental Allergy、Clinical   & Translational Immunology、World   Journal of Otolaryngology Head and Neck Surgery、   Associate Editor of Chinese Journal of Otolaryngology and Neck Surgery and   Clinical Journal of Otolaryngology and Neck Surgery, Editorial Board Member   of Allergy, International Archives of Allergy and Immunology, and other journals.   My research focuses on the pathogenesis and clinical diagnosis and treatment   strategies of chronic sinusitis, nasal polyps, allergic rhinitis, and   olfactory dysfunction. Hosted multiple projects including the National Key   R&D Program, National Natural Science Key Projects, and National Natural   Science Major International (Regional) Cooperative Research Projects, with   sufficient funding. As the corresponding author Nature Immunology、Cellular and Molecular Immunology、Nature Communications、 Journal   of Respiratory and Critical Care Medicine、Journal   of Allergy and Clinical Immunology、Allergy   More than 100 papers have been published in international authoritative   journals.

In recent years, Professor Liu Zheng has established   close cooperative relationships with Academician Ma Guanghui, Academician Yu   Di, Researcher Wei Wei, and Professor Wu Ning's team, creating an innovative   model and research platform that integrates research institutes and   hospitals. Facing the major challenges of the pathogenesis and diagnosis and   treatment of nasal inflammatory diseases, he has conducted research on the   pathogenesis and precision treatment based on innovative dosage forms. Some   of the results have been published in Nature Immunology、Science Immunology、Nature   Communications、Journal of Allergy and Clinical   Immunology、Allergy Waiting for international   authoritative journals. The doctoral/postdoctoral students jointly trained by   the team have successfully applied for multiple national level projects such   as the National Excellent Youth Fund.

Research

Chronic sinusitis (CRS) and allergic rhinitis (AR) have a high incidence rate, limited clinical treatment methods, and are prone to relapse, which cause huge economic burden to society. They are difficult and painful points in clinical diagnosis and treatment. The applicant has been engaged in long-term research on the pathogenesis and clinical translation of nasal inflammatory diseases such as CRS and AR, and has achieved systematic innovative results in the analysis of immunopathological features, the function and regulation of immune cells and structural cells, and precision diagnosis and treatment of diseases. As a recipient of the National Natural Science Foundation of China Outstanding Youth Fund, a Changjiang Scholar Distinguished Professor appointed by the Ministry of Education, and a leading talent in scientific and technological innovation under the National Thousand Talents Program, the applicant has served as the corresponding author in the past five years Nature Immunology、Nature Communications、American Journal of Respiratory and Critical Care Medicine、Journal of Allergy and Clinical Immunology Published over 60 SCI papers with international authoritative journals such as Allergy, and won the first prize of the Chinese Medical Science and Technology Award, the first prize of the Hubei Provincial Science and Technology Progress Award, and the first prize of the Hubei Provincial Natural Science Award as the first author.

Representative  Publications

  1. Distinct   immunopathologic characteristics of various types of chronic rhinosinusitis   in adult Chinese. J Allergy Clin Immunol. 2009; 124(3):478-484.    Ping-Ping Cao#, Hua-Bin Li, Bao-Feng Wang,   Shui-Bin Wang, Xue-Jun You, Yong-Hua Cui, De-Yun Wang, Martin Desrosiers, Zheng   Liu*.

  2. Multidimensional   endotypes of chronic rhinosinusitis and their association with treatment   outcomes. Allergy. 2018; 73(7):1459-1469.   Bo   Liao#, Jin-Xin Liu, Zhi-Yong Li, Zhen Zhen, Ping-Ping Cao, Yin Yao, Xiao-Bo   Long, Heng Wang, Yan Wang, Robert Schleimer, Zheng Liu*.

  3. Selenium-GPX4   axis protects follicular helper T cells from ferroptosis. Nat Immunol. 2021;   22(9):1127-1139.     Yin Yao#, Zhian   Chen#, Hao Zhang#, Cailing Chen, Ming Zeng, Joseph Yunis, Yunbo Wei, Yanmin   Wan, Naiqi Wang, Mingzhe Zhou, Chao Qiu, Qunxiong Zeng, Hong Sheng Ong, Hao   Wang, Fadzai Victor Makota, Yang Yang, Zhaohui Yang, Nan Wang, Jun Deng, Chao   Shen, Yan Xia, Lin Yuan, Zhaoqin Lian, Yike Deng, Cuilian Guo, Ao Huang,   Pengcheng Zhou, Haibo Shi, Weitian Zhang, Hongliang Yi, Dongmei Li, Ming Xia,   Jing Fu, Ning Wu, Judy B de Haan, Nan Shen, Wenhong Zhang, Zheng Liu*,   Di Yu*.

  4. Granzyme   K+CD8+ T cells interact with fibroblasts to promote neutrophilic inflammation   in nasal polyps. Nature Communications. 2024; 15(1): 10413.    Cui-Lian Guo#, Chong-Shu Wang#, Zhi-Chao   Wang#, Fei-Fan Liu, Lin Liu, Yang Yang, Xia Li, Bei Guo, Ruo-Yu Lu, Bo Liao,   Jin-Xin Liu, Hai Wang, Jia Song, Yin Yao, Li-Ping Zhu, Di Yu*, Zheng Liu*.  

  5. Succinate   drives gut inflammation by promoting FOXP3 degradation through a molecular   switch. Nat Immunol. 2025; 26(6): 866-880.   Hai   Wang#, Danqing Hu#, Yang Cheng, Qiong Gao, Kun Liu, Nikita L Mani, Amy Y   Tang, Radhika Iyer, Beixue Gao, Leyu Sun, Qi Zhou, Qin Yu, Samuel E Weinberg,   Xiaoyu Zhang, Yingzi Cong, Parambir S Dulai, Yana Zhang*, Zheng Liu*,   Deyu Fang*.

  6. Aberrant   follicular regulatory T cells associate with immunoglobulin hyperproduction   in nasal polyps with ectopic lymphoid tissues. Journal of Allergy and   Clinical Immunology. 2024; 153(4): 1025-1039.    Jia   Song#, Hai Wang#, Zhe-Zheng Wang#, Cui-Lian Guo, Wen-Xuan Xiang, Jing-Xian   Li, Zhi-Chao Wang, Ji-Xin Zhong, Kun Huang, Robert P Schleimer, Yin Yao*, Zheng   Liu*.

  7. Immune   signatures predict response to house dust mite subcutaneous immunotherapy in   patients with allergic rhinitis. Allergy. 2024; 79(5): 1230-1241.     Nan Wang#, Jia Song#, Shi-Ran Sun#,   Ke-Zhang Zhu, Jing-Xian Li, Zhi-Chao Wang, Cui-Lian Guo, Wen-Xuan Xiang,   Yun-Long Tong, Ming Zeng, Heng Wang, Xiao-Yan Xu, Yin Yao*, Zheng Liu*.

  8. Perturbated   glucose metabolism augments epithelial cell proinflammatory function in   chronic rhinosinusitis. Journal of Allergy and Clinical Immunology. 2023;   151(4):991-1004.      Cai-Ling Chen#,   Jin Ma#, Ruo-Yu Lu, Yu-Ting Wang, Jie-Fang Zhao, Yi-Fan Kang, Jun-Jian Hu,   Nan Wang, Jia Song, Jixin Zhong, Chen Chen, Heng Wang*, Zheng Liu*.

  9. Untargeted   metabolomic profiling identifies disease-specific and outcome-related   signatures in chronic rhinosinusitis. Journal of Allergy and Clinical   Immunology. 2022; 150(3): 727-735.      Jing-Xian   Li#, Zhe-Zheng Wang#, Guan-Ting Zhai, Cai-Ling Chen, Ke-Zhang Zhu, Ze Yu, Zheng   Liu*.

  10. Extrafollicular PD-1high CXCR5 - CD4+ T cells participate in local immunoglobulin production in nasal polyps. J Allergy Clin Immunol. 2022; 149(2):610-623.   Zhi-Chao Wang#, Yin Yao#, Cai-Ling Chen, Cui-Lian Guo, Hong-Xia Ding, Jia Song, Zhe-Zheng Wang, Nan Wang, Xue-Li Li, Bo Liao, Yang Yang, Di Yu, Zheng Liu*

Address ：115 Donghu Road, Wuchang District, Wuhan, Hubei Province

E-mail ：office.tkms@whu.edu.cn

© Taikang Center for Life and Medical Sciences of Wuhan University