Metabolism is the fundamental characteristic and functional basis of cellular biological activities, and its homeostasis and process remodeling are important supports for the body to respond to environmental and genetic changes. The imbalance of metabolism in the body leads to the occurrence of various metabolic diseases, as well as various major diseases such as cancer, immunity, neurodegeneration, developmental defects, etc., which is the focus of biomedical research.

We will integrate cutting-edge technologies such as single-cell, single-molecule, multi omics, high-resolution imaging, molecular structure, mass spectrometry imaging, and gene editing, guided by major scientific issues and national needs, to study the core mechanisms of the metabolism of the three major energy substances of sugar, fat, and amino acids, reveal their regulatory directions reshaped in physiological and pathological processes, and promote the translational application of metabolic regulation in the diagnosis and treatment of major diseases.

The main directions include:

1. The molecular network and subcellular architecture regulation of metabolites: the molecular network regulation of the production, transformation, and transportation of metabolites such as sugars, lipids, and amino acids in the body; Quantitatively analyze the spatial distribution of metabolites at the subcellular level; Develop new concepts, techniques, and methods for metabolic research.

2. Cross cellular and cross organizational metabolic information exchange and network regulation: discovering substances (metabolites, nucleic acids, peptides, secreted proteins, secreted organelles such as exosomes, unknown substances, and dark matter) and their regulatory mechanisms involved in intercellular and inter organizational communication; Explore new functions of metabolic tissues, metabolic regulatory effects of other tissues such as nerves and immune systems, and unknown metabolic tissues; New genetic methods, organoid techniques, and multicellular tissue co culture systems.

3. Metabolic regulation in the process of interaction between the environment and the body: studying the metabolic regulation of microorganisms (bacteria, fungi, viruses) and their derivatives, physical factors (light, sound, electricity, magnetism, force), chemical substances (gas and flavor molecules, skincare products, air pollutants, food additives) and the interaction between the environment and the body tissues.

4. Metabolic remodeling and physiological pathological function: Revealing the correlation between different diseases and genetic backgrounds and metabolic changes; Explore the impact of metabolic remodeling on the body's adaptability and disease outcomes; Develop intervention and treatment plans based on metabolic regulation; Study metabolic signals and regulation among different species.