Publications-武汉大学泰康生命医学中心

Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis

Yong Chen, Zhuyin Wu, Shijia Huang, Xiaoxia Wang, Sijia He, Lin Liu, Yurong Hu, Li Chen, Peng Chen, Songzi Liu, Shengqi He, Bo Shan, Ling Zheng, Sheng-Zhong Duan, Zhiyin Song, Lei Jiang, Qiong A. Wang, Zhenji Gan, Bao-Liang Song, Jianmiao Liu, Liangyou Rui, Mengle Shao & Yong Liu Nature Metabolism volume 4, pages1166–1184 (2022)
From N–H Nitration to Controllable Aromatic Mononitration and Dinitration─The Discovery of a Versatile and Powerful N-Nitropyrazole Nitrating Reagent

Tao Yang , Xiaoqian Li, Shuang Deng, Xiaotian Qi, Hengjiang Cong, Hong-Gang Cheng, Liangwei Shi*, Qianghui Zhou*, and Lin Zhuang* https://pubs.acs.org/doi/full/10.1021/jacsau.2c00413
Chromatin conformation of human oral epithelium can identify orofacial cleft missing functional variants

Yao Xiao, Shengbo Jiao, Miao He, Da Lin, Huanyan Zuo, Jiahao Han, Yonghua Sun, Gang Cao, Zhi Chen & Huan Liu International Journal of Oral Science volume 14, Article number: 43 (2022) https://www.nature.com/articles/s41368-022-00194-0
Renal NF-κB activation impairs uric acid homeostasis to promote tumor-associated mortality independent of wasting

Yuchen Chen ,Wenhao Xu ,Yuan Chen ,Jiantao Song ,Xiaoya Zhou ,Wei Song 3 ,Show all authors ,Show footnotes Published:August 26,2022 DOI:https://doi.org/10.1016/j.immuni.2022.07.022
Nature | 宋保亮团队揭示抑制去唾液酸糖蛋白受体ASGR1通过促使胆固醇外排而降脂

胆固醇作为一类脂质小分子，对于哺乳动物生命活动至关重要。机体通过协调胆固醇吸收、合成和外排而维持动态平衡。高浓度胆固醇引发的心血管疾病越来越多【1,2】，降脂是预防和治疗心血管疾病的必要手段。现有的降脂药物如：他汀、依折麦布、PCSK9抑制剂等虽然都能不同程度的降低血脂，但是也存在一定的副作用和局限性【3】，如：他汀和PCSK9抑制剂使血液中胆固醇进入肝脏，改变胆固醇分布，有增加肝脏负担的风险；依折麦布抑制...
Lowering low-density lipoprotein cholesterol: from mechanisms to therapies

Jie Luo, Jin-Kai Wang, Bao-Liang Song Life Metabolism, Volume 1, Issue 1, August 2022, Pages 25–38, Published: 20 May 2022 https://doi.org/10.1093/lifemeta/loac004

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