Dr. Yong Liu received his Bachelor and Master degrees in Biochemistry from Peking University in 1986 and 1989, respectively. He obtained his Ph.D. degree in 1995 in Microbiology and Molecular Genetics from Rutgers-The State University of New Jersey and UMDNJ-RWJ Medical School.
RNA splicing, removal of introns, is an essential step for both coding and non-coding genes during the eukaryotic RNA processing. RNA splicing is catalyzed by the spliceosome, a large and dynamic macromolecular machine that consists of five small nuclear RNAs and >100 proteins. Both splicing fidelity and efficiency are important for generating accurate mRNAs, and thereby functional proteins. Including alternative splicing, trans-splicing, back splicing and minor splicing, diverse selection of splice sites and introns generate multiple RNA isoforms from one gene, which is critical for the regulation of cell development and differentiation. Furthermore, aberrant splicing that caused by mutations in splicing factors or RNA cis-elements has been found in many diseases.
Mutations in key oncogenes drive tumor initiation, and immunosuppressive microenvironment networks suppress tumor immunity. Changes in tumor cell signaling pathways lead to metabolic reprogramming, tumor growth and survival advantages. The interaction between tumor metabolism and microenvironment regulates the occurrence and development of tumors, their response to treatment, and enables tumors to evade immune surveillance
Yuchen XiaE-mail：yuchenxia@whu.edu.cnWebsite：https://wbm.whu.edu.cn/info/1350/5923.htmBiographyDr.Yuchen Xia, is a professor at Wuhan University, School of Basic Medical Sciences, and the director of the Institute of Medical Virology. After graduating with a bachelor's degree in Biotechnology from Wuhan University in 2005, he obtained master's and doctoral degrees from the Wuhan Institute of Virology,...
Professor Yuan Yufeng and his team focus on the pathogenesis of primary liver cancer and metabolic liver disease, as well as the research of the early diagnosis and minimally invasive treatment of hepatobiliary and Pancreatic tumors
1. Functional biomaterials for periodontal regeneration, The National Science Fund for Distinguished Young Scholars (82025011), 01/2021-12/2025 2. Study on the regulation of periodontal microecology and periodontal regeneration by biomimetic bone electrically active materials, The National Key Research and Development Program, 12/2021-11/2024
