Our studies mainly focus on the epigenetic regulation of human diseases, such as cancer and inflammation related diseases. Cancer and inflammation are tightly related and long-tern unresolved inflammation is one of important risk factors for tumorigenesis, such as colitis-associated cancer.
Yuchen XiaE-mail：yuchenxia@whu.edu.cnWebsite：https://wbm.whu.edu.cn/info/1350/5923.htmBiographyDr.Yuchen Xia, is a professor at Wuhan University, School of Basic Medical Sciences, and the director of the Institute of Medical Virology. After graduating with a bachelor's degree in Biotechnology from Wuhan University in 2005, he obtained master's and doctoral degrees from the Wuhan Institute of Virology,...
The Xiang Lab’s research focuses on the developments of multi-dimensional and functional super-resolution imaging techniques to resolve nanoscale heterogeneity for lives and nanomaterials. To achieve this goal, our lab mainly works on the following directions:I. Developments of novel multi-dimensional super-resolution imaging technique to resolve functional information, including diffusivity, polarity, electrical potential, enzyme activity, ion concentration and so on.
RNA splicing, removal of introns, is an essential step for both coding and non-coding genes during the eukaryotic RNA processing. RNA splicing is catalyzed by the spliceosome, a large and dynamic macromolecular machine that consists of five small nuclear RNAs and >100 proteins. Both splicing fidelity and efficiency are important for generating accurate mRNAs, and thereby functional proteins. Including alternative splicing, trans-splicing, back splicing and minor splicing, diverse selection of splice sites and introns generate multiple RNA isoforms from one gene, which is critical for the regulation of cell development and differentiation. Furthermore, aberrant splicing that caused by mutations in splicing factors or RNA cis-elements has been found in many diseases.
Dr. Jie Xu holds the position of professor and serves as the principal investigator at the TaiKang Center for Life and Medical Sciences within Wuhan University. he is research interests revolve around the central nervous system's pivotal role in regulating metabolism.
1.New genome editing tools2.Next generation delivery systems for therapeutic genome editing
