Prion diseases primarily caused by the conformational conversion of prion protein (PrP) from its cellular form (PrPC) into a pathological aggregated form (PrPSc) in humans, cattle, sheep and cervid species. A major pathological hallmark of Amyotrophic lateral sclerosis (ALS) is the aggregates formed by copper, zinc superoxide dismutase (SOD1) in motor neuron cells.
I have a combinatory background of both clinical dentistry and craniofacial developmental biology also a combinatory research interest in both craniofacial mesenchyme and dental epithelium. My research focuses on "regulation of craniofacial epithelial and mesenchymal lineage fate by genomic non-coding regions" to address the difficulties of precise diagnosis and treatment of craniofacial genetic defects: 1) systemic functional annotation of non-coding DNA and RNA related to craniofacial development, and in-depth excavation of the developmental phase of cranial neural crest mesenchymal and epithelial cells
My research interest focuses on developing novel technologies for DNA methylation analysis using chemical and biochemical approaches, with a primary application in the field of cancer early screening and related biomedical research.
Dr. Yong Liu received his Bachelor and Master degrees in Biochemistry from Peking University in 1986 and 1989, respectively. He obtained his Ph.D. degree in 1995 in Microbiology and Molecular Genetics from Rutgers-The State University of New Jersey and UMDNJ-RWJ Medical School.
Cells are the fundamental units of biological systems, and various proteins inside and outside the cell work with the precision of mechanical parts, enabling cells to navigate complex physiological environments and fulfill their biological functions. Our laboratory is primarily engaged in developing and utilizing novel photonic and biophysical tools to study the physical principles underlying cellular movement processes (from single molecules to living cells) and to explore the significance of these physical principles in biology.
Currently, invasive fungal infections are devastating due to the widespread use of broad-spectrum antibiotics and interventional treatment. Among them, Candida albicans is one of the most prevalent opportunistic pathogenic fungi in the humans, responsible for 60-70% of invasive fungal infections.
